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    ravA regulatory ATPase RavA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948256, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ravA
    Official Full Name
    regulatory ATPase RavA
    Primary source
    ECOCYC:EG11731
    Locus tag
    b3746
    See related
    ASAP:ABE-0012247
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3740; yieN
    Summary
    In rpoS-regulated operon with viaA. [More information is available at EcoGene: EG11731]. RavA belongs to the MoxR family of AAA+ ATPases. [More information is available at EcoCyc: EG11731].
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    Genomic context

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    Sequence:
    NC_000913.3 (3929597..3931093, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator AsnC Neighboring gene asparagine synthetase A Neighboring gene protein ViaA Neighboring gene K(+):H(+) symporter Kup Neighboring gene D-ribose pyranase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane. Felix J, et al. Nat Commun, 2022 Sep 20. PMID 36127320, Free PMC Article
    2. Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins. Malet H, et al. Elife, 2014 Aug 5. PMID 25097238, Free PMC Article
    3. The MoxR ATPase RavA and its cofactor ViaA interact with the NADH:ubiquinone oxidoreductase I in Escherichia coli. Wong KS, et al. PLoS One, 2014. PMID 24454883, Free PMC Article
    4. Formation of a distinctive complex between the inducible bacterial lysine decarboxylase and a novel AAA+ ATPase. Snider J, et al. J Biol Chem, 2006 Jan 20. PMID 16301313
    5. MoxR AAA+ ATPases: a novel family of molecular chaperones? Snider J, et al. J Struct Biol, 2006 Oct. PMID 16677824

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane.
      Title: The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane.
    2. The structural principles of the LdcI-RavA interaction are being described using molecular modeling.
      Title: Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins.
    3. Data show that the RavA structure provides insights into how five RavA hexamers interact with two LdcI/CadA decamers to form the RavA-LdcI/CadA cage-like structure.
      Title: Structure of RavA MoxR AAA+ protein reveals the design principles of a molecular cage modulating the inducible lysine decarboxylase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulatory ATPase RavA
    NP_418202.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3929597..3931093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418202.4 regulatory ATPase RavA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418202.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A895NYP4
      Conserved Domains (1) summary
      PRK13531
      Location:1 → 498
      PRK13531; regulatory ATPase RavA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials