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    phnI carbon-phosphorus lyase core complex subunit PhnI [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948605, updated on 3-Dec-2024

    Summary

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    Official Symbol
    phnI
    Official Full Name
    carbon-phosphorus lyase core complex subunit PhnI
    Primary source
    ECOCYC:EG10718
    Locus tag
    b4099
    See related
    ASAP:ABE-0013428
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4092
    Summary
    Phosphonate utilization is cryptic in K-12. [More information is available at EcoGene: EG10718]. PhnI is required for the use of phosphonate as a phosphorus source. phnI is part of an operon that is phosphate starvation inducible and required for use of phosphonate and phosphite as phosphorus sources . phnI is required for use of phosphonates but not for uptake . [More information is available at EcoCyc: EG10718].
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    Genomic context

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    Sequence:
    NC_000913.3 (4319599..4320663, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene RPnTP hydrolase Neighboring gene methylphosphonate degradation complex subunit PhnL Neighboring gene carbon-phosphorus lyase subunit PhnK Neighboring gene carbon-phosphorus lyase core complex subunit PhnJ Neighboring gene carbon-phosphorus lyase core complex subunit PhnH Neighboring gene carbon-phosphorus lyase core complex subunit PhnG Neighboring gene putative transcriptional regulator PhnF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into the bacterial carbon-phosphorus lyase machinery. Seweryn P, et al. Nature, 2015 Sep 3. PMID 26280334, Free PMC Article
    2. Subunit Interactions within the Carbon-Phosphorus Lyase Complex from Escherichia coli. Ren Z, et al. Biochemistry, 2015 Jun 2. PMID 25954983, Free PMC Article
    3. Structures of the Carbon-Phosphorus Lyase Complex Reveal the Binding Mode of the NBD-like PhnK. Yang K, et al. Structure, 2016 Jan 5. PMID 26724995, Free PMC Article
    4. Five phosphonate operon gene products as components of a multi-subunit complex of the carbon-phosphorus lyase pathway. Jochimsen B, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21705661, Free PMC Article
    5. Mapping and molecular cloning of the phn (psiD) locus for phosphonate utilization in Escherichia coli. Wanner BL, et al. J Bacteriol, 1990 Mar. PMID 2155195, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within organic phosphonate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic phosphonate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in organic phosphonate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic phosphonate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of carbon phosphorus lyase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of carbon phosphorus lyase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbon-phosphorus lyase core complex subunit PhnI
    NP_418523.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4319599..4320663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418523.1 carbon-phosphorus lyase core complex subunit PhnI [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418523.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AMT4
      Conserved Domains (1) summary
      COG3626
      Location:1 → 354
      PhnI; Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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