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    insA1 IS1 family protein InsA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948449, updated on 17-Dec-2024

    Summary

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    Official Symbol
    insA1
    Official Full Name
    IS1 family protein InsA
    Primary source
    ECOCYC:G6086
    Locus tag
    b0022
    See related
    ASAP:ABE-0000078
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0023
    Summary
    IS1 is inserted in 7 locations in MG1655, designated IS1ABCDEFH; IS1G is specific to the W3110 K-12 chromosome. [More information is available at EcoGene: EG60003]. IS1 is the smallest insertion sequence in Escherichia coli. [More information is available at EcoCyc: G6086].
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    Genomic context

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    Sequence:
    NC_000913.3 (20233..20508, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Na(+):H(+) antiporter NhaA Neighboring gene DNA-binding transcriptional activator NhaR Neighboring gene IS1 family protein InsB Neighboring gene 30S ribosomal subunit protein S20 Neighboring gene DUF2575 domain-containing protein YaaY

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IS1R-mediated plasticity of IncL/M plasmids leads to the insertion of bla OXA-48 into the Escherichia coli Chromosome. Beyrouthy R, et al. Antimicrob Agents Chemother, 2014 Jul. PMID 24752261, Free PMC Article
    2. Genetic analyses of the interactions of the IS1-encoded proteins with the left end of IS1 and its insertion hotspot. Matsutani S. J Mol Biol, 1997 Apr 4. PMID 9126837
    3. The insE open reading frame of IS1 is not required for formation of cointegrates. Freund ET, et al. J Bacteriol, 1996 Apr. PMID 8636048, Free PMC Article
    4. Frameshifting is required for production of the transposase encoded by insertion sequence 1. Sekine Y, et al. Proc Natl Acad Sci U S A, 1989 Jun. PMID 2543983, Free PMC Article
    5. Four types of IS1 with differences in nucleotide sequence reside in the Escherichia coli K-12 chromosome. Umeda M, et al. Gene, 1991 Feb 1. PMID 1849492

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these findings indicate a plasticity of the OXA-48 genetic environment mediated by IS1R insertion sequences
      Title: IS1R-mediated plasticity of IncL/M plasmids leads to the insertion of bla OXA-48 into the Escherichia coli Chromosome.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA transposition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA transposition IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA transposition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transposition IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IS1 family protein InsA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      20233..20508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414563.1 IS1 family protein InsA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414563.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A170TVE0, A0A377C0U4, A0A3S4K392, A0A509DNY3, A0AAE9U4P9, A0AAV1IQ97, A0AAX2JML7, A7ZGQ4, C3UUR6, D7GKB4, Q6KD64, Q849W1
      Conserved Domains (1) summary
      NF033558
      Location:8 → 91
      transpos_IS1; IS1 family transposase
    Nucleotide Protein
    Heading Accession and Version

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