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    ddlB D-alanine--D-alanine ligase B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946324, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ddlB
    Official Full Name
    D-alanine--D-alanine ligase B
    Primary source
    ECOCYC:EG10214
    Locus tag
    b0092
    See related
    ASAP:ABE-0000326
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ddl; ECK0093
    Summary
    The protein has been crystallized. [More information is available at EcoCyc: EG10214].
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    Genomic context

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    Sequence:
    NC_000913.3 (102233..103153)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Neighboring gene peptidoglycan glycosyltransferase FtsW Neighboring gene N-acetylglucosaminyl transferase Neighboring gene UDP-N-acetylmuramate--L-alanine ligase Neighboring gene cell division protein FtsQ Neighboring gene cell division protein FtsA Neighboring gene cell division protein FtsZ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB). Sova M, et al. Bioorg Med Chem Lett, 2009 Mar 1. PMID 19196510
    2. Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening. Kovac A, et al. J Med Chem, 2008 Dec 11. PMID 19053785
    3. Temperature-sensitive mutant of Escherichia coli K-12 with an impaired D-alanine:D-alanine ligase. Lugtenberg EJ, et al. J Bacteriol, 1973 Jan. PMID 4567144, Free PMC Article
    4. Further evidence for overlapping transcriptional units in an Escherichia coli cell envelope-cell division gene cluster: DNA sequence and transcriptional organization of the ddl ftsQ region. Robinson AC, et al. J Bacteriol, 1986 Sep. PMID 3528126, Free PMC Article
    5. Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B. Park IS, et al. Biochemistry, 1996 Aug 13. PMID 8756703

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: D-alanine: D-alanine ligase of Escherichia coli. Expression, purification and inhibitory studies on the cloned enzyme.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-alanine-D-alanine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-alanine-D-alanine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-alanine-D-alanine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-alanine-D-alanine ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-alanine--D-alanine ligase B
    NP_414634.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      102233..103153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414634.1 D-alanine--D-alanine ligase B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414634.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1PKJ5
      Conserved Domains (1) summary
      PRK01372
      Location:1 → 306
      ddl; D-alanine--D-alanine ligase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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