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    dinJ antitoxin/DNA-binding transcriptional repressor DinJ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944914, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dinJ
    Official Full Name
    antitoxin/DNA-binding transcriptional repressor DinJ
    Primary source
    ECOCYC:G6110
    Locus tag
    b0226
    See related
    ASAP:ABE-0000764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0227; sosA
    Summary
    Coexpression of DinJ with YafQ blocks the growth inhibition of YafQ (Motiejunaite, 2007; Szekeres, 2007). [More information is available at EcoGene: EG13142]. The YafQ-DinJ toxin-antitoxin system was identified by its similarity to the RelE-RelB toxin-antitoxin system . [More information is available at EcoCyc: G6110].
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    Genomic context

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    Sequence:
    NC_000913.3 (246242..246502, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative glutamine amidotransferase YafJ Neighboring gene peptidoglycan meso-diaminopimelic acid protein amidase A Neighboring gene ribosome-dependent mRNA interferase toxin YafQ Neighboring gene NlpC/P60 family protein YafL Neighboring gene REP-associated tyrosine transposase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antitoxin DinJ influences the general stress response through transcript stabilizer CspE. Hu Y, et al. Environ Microbiol, 2012 Mar. PMID 22026739, Free PMC Article
    2. Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ. Ruangprasert A, et al. J Biol Chem, 2014 Jul 25. PMID 24898247, Free PMC Article
    3. Characterization of Escherichia coli dinJ-yafQ toxin-antitoxin system using insights from mutagenesis data. Armalyte J, et al. J Bacteriol, 2012 Mar. PMID 22247505, Free PMC Article
    4. Toxin-antitoxin modules as bacterial metabolic stress managers. Buts L, et al. Trends Biochem Sci, 2005 Dec. PMID 16257530
    5. Hypothetical functions of toxin-antitoxin systems. Magnuson RD. J Bacteriol, 2007 Sep. PMID 17616596, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DinJ is involved in mediating the general stress response by indirect regulation of RpoS via its direct control of cspE
      Title: Antitoxin DinJ influences the general stress response through transcript stabilizer CspE.
    2. The endoribonuclease activity of YafQ was inhibited in the complex with DinJ antitoxin in vitro.
      Title: Characterization of Escherichia coli dinJ-yafQ toxin-antitoxin system using insights from mutagenesis data.
    3. acts as antitoxin in active toxin-antitoxin module with YafQ.
      Title: Escherichia coli dinJ-yafQ genes act as a toxin-antitoxin module.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables toxic substance binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables toxic substance binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in single-species biofilm formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in single-species biofilm formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antitoxin/DNA-binding transcriptional repressor DinJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      246242..246502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414761.1 antitoxin/DNA-binding transcriptional repressor DinJ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414761.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q47150
      Conserved Domains (1) summary
      pfam04221
      Location:4 → 83
      RelB; RelB antitoxin
    Nucleotide Protein
    Heading Accession and Version

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