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    hemB porphobilinogen synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945017, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hemB
    Official Full Name
    porphobilinogen synthase
    Primary source
    ECOCYC:EG10428
    Locus tag
    b0369
    See related
    ASAP:ABE-0001266
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0366; ncf
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    Genomic context

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    Sequence:
    NC_000913.3 (388753..389727, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene taurine ABC transporter ATP binding subunit Neighboring gene taurine ABC transporter membrane subunit Neighboring gene taurine dioxygenase Neighboring gene pseudo Neighboring gene protein YtiB Neighboring gene IS3 element protein InsF Neighboring gene IS3 element protein InsE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Escherichia coli expression-based method for heme substitution. Woodward JJ, et al. Nat Methods, 2007 Jan. PMID 17187078
    2. Oxygen sensitivity of an Escherichia coli mutant. Adler H, et al. J Bacteriol, 1992 Apr. PMID 1551829, Free PMC Article
    3. Genetic and molecular analysis of spontaneous respiratory deficient (res-) mutants of Escherichia coli K-12. Lewis LA, et al. Microbiol Immunol, 1991. PMID 1943842
    4. Nucleotide sequence of the hemB gene of Escherichia coli K12. Echelard Y, et al. Mol Gen Genet, 1988 Nov. PMID 2464127
    5. Cloning of the Escherichia coli K-12 hemB gene. Li JM, et al. J Bacteriol, 1988 Feb. PMID 3276659, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Purification and characterization of 5-aminolaevulinic acid dehydratase from Escherichia coli and a study of the reactive thiols at the metal-binding domain.
    2. The Porphobilinogen synthase (PBGS) is as an enzyme that may exhibit phylogenetic diversity in its chemical reaction mechanism.
      Title: The porphobilinogen synthase catalyzed reaction mechanism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables porphobilinogen synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables porphobilinogen synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables porphobilinogen synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables porphobilinogen synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrapyrrole biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    porphobilinogen synthase
    NP_414903.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      388753..389727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414903.4 porphobilinogen synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414903.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6BLR2
      Conserved Domains (1) summary
      PRK09283
      Location:1 → 319
      PRK09283; porphobilinogen synthase
    Nucleotide Protein
    Heading Accession and Version

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