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    mak fructokinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949086, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mak
    Official Full Name
    fructokinase
    Primary source
    ECOCYC:EG11288
    Locus tag
    b0394
    See related
    ASAP:ABE-0001372
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0389; yajF
    Summary
    Mak also has low level glucokinase activity; fructose is a much substrate than glucose in vitro. [More information is available at EcoGene: EG11288]. In the absence of the usual PTS-mediated route of fructose uptake, Mak catalyzes phosphorylation of fructose after its entry into the cell via PtsGF . [More information is available at EcoCyc: EG11288].
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    Genomic context

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    Sequence:
    NC_000913.3 (410144..411052)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene protein YkiD Neighboring gene nucleoid-associated protein RdgC Neighboring gene putative transport protein AraJ Neighboring gene ATP-dependent structure-specific DNA nuclease - SbcC subunit Neighboring gene ATP-dependent structure-specific DNA nuclease - SbcD subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic control of manno(fructo)kinase activity in Escherichia coli. Sproul AA, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11742072, Free PMC Article
    2. Purification and properties of the mannokinase from Escherichia coli. Sebastian J, et al. Arch Biochem Biophys, 1972 Jul. PMID 4557975
    3. Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases. Miller BG, et al. Biochemistry, 2005 Aug 16. PMID 16086580
    4. Facilitated diffusion of fructose via the phosphoenolpyruvate/glucose phosphotransferase system of Escherichia coli. Kornberg HL, et al. Proc Natl Acad Sci U S A, 2000 Feb 15. PMID 10677538, Free PMC Article
    5. Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases. Miller BG, et al. Biochemistry, 2004 Jun 1. PMID 15157072

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fructokinase
    NP_414928.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      410144..411052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414928.2 fructokinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414928.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X5F1, A0A8T3UGY4
      Conserved Domains (1) summary
      PRK09557
      Location:1 → 301
      PRK09557; fructokinase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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