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    yajC Sec translocon accessory complex subunit YajC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945374, updated on 17-Dec-2024

    Summary

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    Official Symbol
    yajC
    Official Full Name
    Sec translocon accessory complex subunit YajC
    Primary source
    ECOCYC:EG11096
    Locus tag
    b0407
    See related
    ASAP:ABE-0001415
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0401
    Summary
    YajC is found in the heterotrimeric complex SecDFYajC, a heterotetrameric complex secDFYajC-YidC which can bind to SecYEG, and in an abundant ~56 kDa homoligomeric complex (Nouwen, 2002; Stenberg, 2005). [More information is available at EcoGene: EG11096]. YajC is a member of the SecD/SecF/YajC/YidC complex, which functions in concert with SecYEG to stabilize the insertion of SecA and its bound preprotein into the inner membrane. [More information is available at EcoCyc: EG11096].
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    Genomic context

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    Sequence:
    NC_000913.3 (427287..427619)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase Neighboring gene tRNA-guanine transglycosylase Neighboring gene Sec translocon accessory complex subunit SecD Neighboring gene Sec translocon accessory complex subunit SecF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. vacC, a virulence-associated chromosomal locus of Shigella flexneri, is homologous to tgt, a gene encoding tRNA-guanine transglycosylase (Tgt) of Escherichia coli K-12. Durand JM, et al. J Bacteriol, 1994 Aug. PMID 8045893, Free PMC Article
    2. Stoichiometry of SecYEG in the active translocase of Escherichia coli varies with precursor species. Mao C, et al. Proc Natl Acad Sci U S A, 2013 Jul 16. PMID 23818593, Free PMC Article
    3. A single copy of SecYEG is sufficient for preprotein translocation. Kedrov A, et al. EMBO J, 2011 Sep 6. PMID 21897368, Free PMC Article
    4. Expression, purification and characterization of the Escherichia coli integral membrane protein YajC. Fang J, et al. Protein Pept Lett, 2011 Jun. PMID 21235483
    5. Genetic analysis of SecY: additional export-defective mutations and factors affecting their phenotypes. Taura T, et al. Mol Gen Genet, 1994 May 10. PMID 8190079

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Such lipid enrichment was not found with separately extracted SecDFyajC or YidC, which demonstrates a specific interaction between SecYEG and negatively charged lipids.
      Title: Characterization of the annular lipid shell of the Sec translocon.
    2. Stoichiometry of SecYEG in the active translocase of Escherichia coli varies with precursor species.
      Title: Stoichiometry of SecYEG in the active translocase of Escherichia coli varies with precursor species.
    3. The SecYEG monomer is sufficient to form a functional translocon in the lipid membrane.
      Title: A single copy of SecYEG is sufficient for preprotein translocation.
    4. two mutations confer cold-sensitive phenotype by inactivating the SecDF-YajC complex in protein translocation
      Title: Inactivation of protein translocation by cold-sensitive mutations in the yajC-secDF operon.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein insertion into membrane from inner side IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport by the Sec complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cell envelope Sec protein transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sec translocon accessory complex subunit YajC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      427287..427619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414941.1 Sec translocon accessory complex subunit YajC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414941.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CIL5, A0A1X3IAS8, A0A1X3J609, A0A829L242, A0AA36KUV1, A0AAJ3P000, F4SUM3, Q1RFD4
      Conserved Domains (1) summary
      PRK05585
      Location:3 → 110
      yajC; preprotein translocase subunit YajC; Validated
    Nucleotide Protein
    Heading Accession and Version

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