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    gsk inosine/guanosine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946584, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gsk
    Official Full Name
    inosine/guanosine kinase
    Primary source
    ECOCYC:EG11102
    Locus tag
    b0477
    See related
    ASAP:ABE-0001655
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0471
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    Genomic context

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    Sequence:
    NC_000913.3 (500125..501429)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene adenylate kinase Neighboring gene ferrochelatase Neighboring gene acetylesterase Neighboring gene putative transporter YbaL Neighboring gene fosmidomycin efflux pump

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. End-product regulation and kinetic mechanism of guanosine-inosine kinase from Escherichia coli. Kawasaki H, et al. Biosci Biotechnol Biochem, 2000 May. PMID 10879466
    2. Role of guanosine kinase in the utilization of guanosine for nucleotide synthesis in Escherichia coli. Hove-Jensen B, et al. J Gen Microbiol, 1989 May. PMID 2559948
    3. gsk disruption leads to guanosine accumulation in Escherichia coli. Matsui H, et al. Biosci Biotechnol Biochem, 2001 May. PMID 11440147
    4. Location on the chromosome of Escherichia coli of genes governing purine metabolism. Adenosine deaminase (add), guanosine kinase (gsk) and hypoxanthine phosphoribosyltransferase (hpt). Jochimsen B, et al. Mol Gen Genet, 1975 Dec 30. PMID 765747
    5. Isolation and characterization of visible light-sensitive mutants of Escherichia coli K12. Miyamoto K, et al. J Mol Biol, 1991 Jun 5. PMID 2051480

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Cloning and characterization of the gsk gene encoding guanosine kinase of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within IMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inosine/guanosine kinase
    NP_415010.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      500125..501429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415010.1 inosine/guanosine kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415010.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V1IFM5, A0A1V1IFN1, A0A1V1IFN2, A0A1V1IGJ0, A0A1V1IGM6, A0A376DD56, A0A376RPI7
      Conserved Domains (1) summary
      PRK15074
      Location:1 → 434
      PRK15074; inosine/guanosine kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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