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    acpP acyl carrier protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944805, updated on 3-Dec-2024

    Summary

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    Official Symbol
    acpP
    Official Full Name
    acyl carrier protein
    Primary source
    ECOCYC:EG50003
    Locus tag
    b1094
    See related
    ASAP:ABE-0003703
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1080
    Summary
    Ser36 is phosphopantethylated by AcpS. [More information is available at EcoGene: EG50003]. Acyl carrier protein (ACP) plays an important role in fatty acid biosynthesis. [More information is available at EcoCyc: EG50003].
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    Genomic context

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    Sequence:
    NC_000913.3 (1151615..1151851)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene [acyl-carrier-protein] S-malonyltransferase Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase FabG Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 2 Neighboring gene aminodeoxychorismate lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. Cryle MJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 14. PMID 18838690, Free PMC Article
    2. Antibiotic-free bacterial strain selection using antisense peptide nucleic acid. Dryselius R, et al. Biotechniques, 2003 Nov. PMID 14628680
    3. The translation start codon region is sensitive to antisense PNA inhibition in Escherichia coli. Dryselius R, et al. Oligonucleotides, 2003. PMID 15025910
    4. Protein function microarrays based on self-immobilizing and self-labeling fusion proteins. Sielaff I, et al. Chembiochem, 2006 Jan. PMID 16342318
    5. Gene-specific random mutagenesis of Escherichia coli in vivo: isolation of temperature-sensitive mutations in the acyl carrier protein of fatty acid synthesis. De Lay NR, et al. J Bacteriol, 2006 Jan. PMID 16352845, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
      Title: Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
    2. analysis of acyl carrier protein conserved modular elements and their roles in lipid synthesis
      Title: The conserved modular elements of the acyl carrier proteins of lipid synthesis are only partially interchangeable.
    3. The studies highlight key interactions of transient ACP-LpxD protein complexes and define the dynamic movements of ACP that facilitate substrate delivery and trigger complex dissociation.
      Title: Crystal structures of acyl carrier protein in complex with two catalytic partners show a dynamic role in cellular metabolism.
    4. crystal structures of three forms of Escherichia coli acyl carrier protein engaging LpxD, which represent stalled substrate and liberated products along the reaction coordinate
      Title: Chasing acyl carrier protein through a catalytic cycle of lipid A production.
    5. ACP must be able to adopt a folded conformation for biological activity, and its function does not require complete unfolding of the protein
      Title: Intein-mediated cyclization of bacterial acyl carrier protein stabilizes its folded conformation but does not abolish function.
    6. Studies shed light on a key aspect of ACP biology and provide insights into the mechanism involved.
      Title: Catalysis and mechanism of malonyl transferase activity in type II fatty acid biosynthesis acyl carrier proteins.
    7. solution structures determined of three different forms of ACP, apo-ACP, ACP, and butyryl-ACP under identical experimental conditions; structural studies revealed that attachment of butyryl acyl intermediate to ACP alters the conformation of ACP
      Title: Structural modification of acyl carrier protein by butyryl group.
    8. N-terminus verified by Edman degradation on mature peptide
      Title: Amounts of proteins altered by mutations in the dnaA gene of Escherichia coli.
    9. Study characterizes the physical interaction between SpoT and acyl carrier protein (ACP) using affinity co-purifications and two-hybrid in E. coli.
      Title: Acyl carrier protein/SpoT interaction, the switch linking SpoT-dependent stress response to fatty acid metabolism.
    10. crystallographic analysis of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli
      Title: Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acyl binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyl binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acyl carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl carrier activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyl carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphopantetheine binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acyl carrier protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1151615..1151851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415612.1 acyl carrier protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415612.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AWB3
      Conserved Domains (1) summary
      PRK00982
      Location:1 → 78
      acpP; acyl carrier protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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