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    potA spermidine preferential ABC transporter ATP binding subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946323, updated on 3-Dec-2024

    Summary

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    Official Symbol
    potA
    Official Full Name
    spermidine preferential ABC transporter ATP binding subunit
    Primary source
    ECOCYC:EG10749
    Locus tag
    b1126
    See related
    ASAP:ABE-0003796
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1112
    Summary
    PotBCAD spermidine/putrescine ABC transport system. [More information is available at EcoGene: EG10749]. PotABCD is an ATP-dependent polyamine transporter that is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10749].
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    Genomic context

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    Sequence:
    NC_000913.3 (1184458..1185594, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene spermidine preferential ABC transporter periplasmic binding protein Neighboring gene spermidine preferential ABC transporter membrane subunit PotC Neighboring gene spermidine preferential ABC transporter membrane subunit PotB Neighboring gene peptidase T Neighboring gene 50S ribosomal protein L16-arginine 3-hydroxylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ATPase activity and the functional domain of PotA, a component of the sermidine-preferential uptake system in Escherichia coli. Kashiwagi K, et al. J Biol Chem, 2002 Jul 5. PMID 11976340
    2. Identification and functions of amino acid residues in PotB and PotC involved in spermidine uptake activity. Higashi K, et al. J Biol Chem, 2010 Dec 10. PMID 20937813, Free PMC Article
    3. Effects of ethyl and benzyl analogues of spermine on Escherichia coli peptidyltransferase activity, polyamine transport, and cellular growth. Karahalios P, et al. J Bacteriol, 1999 Jul. PMID 10383956, Free PMC Article
    4. Characteristics of the gene for a spermidine and putrescine transport system that maps at 15 min on the Escherichia coli chromosome. Furuchi T, et al. J Biol Chem, 1991 Nov 5. PMID 1939142
    5. Physical mapping of the Escherichia coli pepT and potABCD genes. Lombardo MJ, et al. J Bacteriol, 1993 Dec. PMID 8244951, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ABC-type polyamine transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ABC-type polyamine transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type polyamine transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ABC-type putrescine transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in polyamine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within putrescine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in putrescine transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within spermidine transmembrane transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within spermidine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within spermidine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermidine transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ATP-binding cassette (ABC) transporter complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spermidine preferential ABC transporter ATP binding subunit
    NP_415644.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1184458..1185594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415644.1 spermidine preferential ABC transporter ATP binding subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415644.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NH81
      Conserved Domains (1) summary
      PRK09452
      Location:4 → 378
      potA; spermidine/putrescine ABC transporter ATP-binding protein PotA
    Nucleotide Protein
    Heading Accession and Version

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