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    abgB p-aminobenzoyl-glutamate hydrolase subunit B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945950, updated on 3-Dec-2024

    Summary

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    Official Symbol
    abgB
    Official Full Name
    p-aminobenzoyl-glutamate hydrolase subunit B
    Primary source
    ECOCYC:G6669
    Locus tag
    b1337
    See related
    ASAP:ABE-0004491
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1333; ydaI
    Summary
    abgAB expression is required for catabolism to feed p-aminobenzoate auxotrophs (Hussein, 1998; Carter, 2007). [More information is available at EcoGene: EG13351]. AbgB appears to have detectable p-aminobenzoyl-glutamate hydrolase activity but is not essential for use of exogenously added p-aminobenzoyl-glutamate . [More information is available at EcoCyc: G6669].
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    Genomic context

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    Sequence:
    NC_000913.3 (1401810..1403255, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene methylated-DNA--[protein]-cysteine S-methyltransferase Neighboring gene p-aminobenzoyl glutamate:H(+) symporter Neighboring gene p-aminobenzoyl-glutamate hydrolase subunit A Neighboring gene putative LysR-type DNA-binding transcriptional regulator AbgR Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD). Bartsch K, et al. J Bacteriol, 1990 Dec. PMID 2254272, Free PMC Article
    2. Purification and characterization of the folate catabolic enzyme p-aminobenzoyl-glutamate hydrolase from Escherichia coli. Green JM, et al. J Bacteriol, 2010 May. PMID 20190044, Free PMC Article
    3. Escherichia coli abg genes enable uptake and cleavage of the folate catabolite p-aminobenzoyl-glutamate. Carter EL, et al. J Bacteriol, 2007 May. PMID 17307853, Free PMC Article
    4. Characterization of mutations that allow p-aminobenzoyl-glutamate utilization by Escherichia coli. Hussein MJ, et al. J Bacteriol, 1998 Dec. PMID 9829935, Free PMC Article
    5. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables dipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables para-aminobenzoyl-glutamate hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables para-aminobenzoyl-glutamate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables para-aminobenzoyl-glutamate hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in folic acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in folic acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within folic acid catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    p-aminobenzoyl-glutamate hydrolase subunit B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1401810..1403255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415853.1 p-aminobenzoyl-glutamate hydrolase subunit B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415853.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7K1X1
      Conserved Domains (1) summary
      cd05673
      Location:12 → 458
      M20_Acy1L2_AbgB; M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily
    Nucleotide Protein
    Heading Accession and Version

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