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    cnu H-NS- and StpA-binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946152, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cnu
    Official Full Name
    H-NS- and StpA-binding protein
    Primary source
    ECOCYC:G6869
    Locus tag
    b1625
    See related
    ASAP:ABE-0005443
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1621; ydgT
    Summary
    Cnu and Hha are paralogs. [More information is available at EcoGene: EG14303]. Cnu is a paralog of the Hha protein and can partially compensate for hha-induced phenotypes. [More information is available at EcoCyc: G6869].
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    Genomic context

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    Sequence:
    NC_000913.3 (1704949..1705164)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase YdgJ Neighboring gene beta-lactam resistance protein Neighboring gene DUF2569 domain-containing inner membrane protein YdgK Neighboring gene SoxR [2Fe-2S] reducing system protein RsxA Neighboring gene SoxR [2Fe-2S] reducing system protein RsxB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Controlling biofilm formation, prophage excision and cell death by rewiring global regulator H-NS of Escherichia coli. Hong SH, et al. Microb Biotechnol, 2010 May. PMID 21255333, Free PMC Article
    2. Structure of the nucleoid-associated protein Cnu reveals common binding sites for H-NS in Cnu and Hha. Bae SH, et al. Biochemistry, 2008 Feb 19. PMID 18189420
    3. Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid. Coombes BK, et al. Proc Natl Acad Sci U S A, 2005 Nov 29. PMID 16301528, Free PMC Article
    4. A mutational study of Cnu reveals attractive forces between Cnu and H-NS. Yun SH, et al. Mol Cells, 2012 Feb. PMID 22358512, Free PMC Article
    5. Repression of intracellular virulence factors in Salmonella by the Hha and YdgT nucleoid-associated proteins. Silphaduang U, et al. J Bacteriol, 2007 May. PMID 17307861, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CnuK9E H-NS complex antagonizes DNA binding of DicA and leads to temperature-dependent filamentous growth in Escherichia coli.
      Title: The CnuK9E H-NS complex antagonizes DNA binding of DicA and leads to temperature-dependent filamentous growth in E. coli.
    2. the attractive force that governs the Cnu-H-NS interaction is an ionic bond, unlike the hydrophobic interaction that is the major attractive force in most proteins.
      Title: A mutational study of Cnu reveals attractive forces between Cnu and H-NS.
    3. interacts both with H-NS and with StpA in vivo
      Title: YdgT, the Hha paralogue in Escherichia coli, forms heteromeric complexes with H-NS and StpA.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bacterial nucleoid packaging ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of single-species biofilm formation on inanimate substrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of termination of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of H-NS-Cnu complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in bacterial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    H-NS- and StpA-binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1704949..1705164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416142.1 H-NS- and StpA-binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416142.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK10391
      Location:1 → 71
      PRK10391; transcription modulator YdgT
    Nucleotide Protein
    Heading Accession and Version

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