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    znuA Zn(2(+)) ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946375, updated on 3-Dec-2024

    Summary

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    Official Symbol
    znuA
    Official Full Name
    Zn(2(+)) ABC transporter periplasmic binding protein
    Primary source
    ECOCYC:G7017
    Locus tag
    b1857
    See related
    ASAP:ABE-0006191
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1858; yebL; yzzP
    Summary
    [More information is available at EcoCyc: G7017].
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    Genomic context

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    Sequence:
    NC_000913.3 (1941651..1942583, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Lipid A biosynthesis myristoyltransferase Neighboring gene peptidoglycan endopeptidase MepM Neighboring gene Zn(2(+)) ABC transporter ATP binding subunit Neighboring gene Zn(2(+)) ABC transporter membrane subunit Neighboring gene Holliday junction branch migration complex subunit RuvB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli. Yatsunyk LA, et al. J Biol Inorg Chem, 2008 Feb. PMID 18027003, Free PMC Article
    2. Crystal structure of the zinc-binding transport protein ZnuA from Escherichia coli reveals an unexpected variation in metal coordination. Li H, et al. J Mol Biol, 2007 May 18. PMID 17399739
    3. Structural analysis of ABC-family periplasmic zinc binding protein provides new insights into mechanism of ligand uptake and release. Chandra BR, et al. J Mol Biol, 2007 Apr 6. PMID 17306297, Free PMC Article
    4. Periplasmic competition for zinc uptake between the metallochaperone ZnuA and Cu,Zn superoxide dismutase. Berducci G, et al. FEBS Lett, 2004 Jul 2. PMID 15225650
    5. Severe zinc depletion of Escherichia coli: roles for high affinity zinc binding by ZinT, zinc transport and zinc-independent proteins. Graham AI, et al. J Biol Chem, 2009 Jul 3. PMID 19377097, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The crystal structures of E. coli ZnuA (Eco-ZnuA) in the apo, Zn(2+)-bound, and Co(2+)-bound forms have been determined.
      Title: Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    3. Crystal structure of the high-affinity zinc transporter ZnuA from Escherichia coli at 1.8 A resolution.
      Title: Structural analysis of ABC-family periplasmic zinc binding protein provides new insights into mechanism of ligand uptake and release.
    4. Data show that the crystal structure of the zinc-binding transport protein ZnuA from Escherichia coli reveals an unexpected variation in metal coordination.
      Title: Crystal structure of the zinc-binding transport protein ZnuA from Escherichia coli reveals an unexpected variation in metal coordination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within zinc ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zn(2(+)) ABC transporter periplasmic binding protein
    NP_416371.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1941651..1942583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416371.4 Zn(2(+)) ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416371.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8R216, A0A7T2J4Z6
      Conserved Domains (1) summary
      PRK09545
      Location:2 → 308
      znuA; zinc ABC transporter substrate-binding protein ZnuA
    Nucleotide Protein
    Heading Accession and Version

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