U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cmoA carboxy-S-adenosyl-L-methionine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946380, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cmoA
    Official Full Name
    carboxy-S-adenosyl-L-methionine synthase
    Primary source
    ECOCYC:G7020
    Locus tag
    b1870
    See related
    ASAP:ABE-0006237
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1871; yecO
    Summary
    CmoA catalyzes an intermediate step(s) in tRNA(cmo5U34) and tRNA(mcmo5U34) synthesis that forms uridine-5-oxyacetic acid (cmo5U) and uridine-5-oxyacetic acid methyl ester (mcmo5U) in tRNA. [More information is available at EcoGene: EG14033].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1952702..1953445)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene isochorismatase family protein YecD Neighboring gene DUF72 domain-containing protein YecE Neighboring gene MAPEG family inner membrane protein YecN Neighboring gene tRNA U34 carboxymethyltransferase Neighboring gene trimethylamine N-oxide reductase 2 Neighboring gene cytochrome c quinol dehydrogenase TorY

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine. Lim K, et al. Proteins, 2001 Dec 1. PMID 11746687
    2. S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA. Byrne RT, et al. Acta Crystallogr D Biol Crystallogr, 2013 Jun. PMID 23695253, Free PMC Article
    3. On the biosynthesis of 5-methoxyuridine and uridine-5-oxyacetic acid in specific procaryotic transfer RNAs. Murao K, et al. Nucleic Acids Res, 1978 Apr. PMID 418384, Free PMC Article
    4. Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases. Feder M, et al. Gene, 2003 Jan 2. PMID 12527203
    5. A method for isolation of Escherichia coli mutants with aberrant RNA methylation using translocatable drug resistance elements. Björk GR, et al. Acta Chem Scand B, 1979. PMID 93836

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxyl- or carbamoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    carboxy-S-adenosyl-L-methionine synthase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1952702..1953445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416384.1 carboxy-S-adenosyl-L-methionine synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416384.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376K6I2, A0A5B9AJ69
      Conserved Domains (1) summary
      TIGR00740
      Location:4 → 242
      TIGR00740; tRNA (cmo5U34)-methyltransferase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.