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    hchA protein/nucleic acid deglycase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946481, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hchA
    Official Full Name
    protein/nucleic acid deglycase 1
    Primary source
    ECOCYC:G7055
    Locus tag
    b1967
    See related
    ASAP:ABE-0006529
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1963; yedU; yzzC
    Summary
    Important for the processing of 8-12mer peptides in vivo. [More information is available at EcoGene: EG11755]. Hsp31 (YedU) is a chaperone that is active as a homodimer . [More information is available at EcoCyc: G7055].
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    Genomic context

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    Sequence:
    NC_000913.3 (2035835..2036686)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene sensor histidine kinase HprS Neighboring gene DNA-binding transcriptional dual regulator HprR Neighboring gene hydroxyisourate hydrolase/transthyretin-related protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hsp31, the Escherichia coli yedU gene product, is a molecular chaperone whose activity is inhibited by ATP at high temperatures. Sastry MS, et al. J Biol Chem, 2002 Nov 29. PMID 12235139
    2. Escherichia coli Hsp31 functions as a holding chaperone that cooperates with the DnaK-DnaJ-GrpE system in the management of protein misfolding under severe stress conditions. Mujacic M, et al. Mol Microbiol, 2004 Feb. PMID 14731284
    3. The linker-loop region of Escherichia coli chaperone Hsp31 functions as a gate that modulates high-affinity substrate binding at elevated temperatures. Sastry MS, et al. Proc Natl Acad Sci U S A, 2004 Jun 8. PMID 15173574, Free PMC Article
    4. A new native EcHsp31 structure suggests a key role of structural flexibility for chaperone function. Quigley PM, et al. Protein Sci, 2004 Jan. PMID 14691241, Free PMC Article
    5. The crystal structure of Escherichia coli heat shock protein YedU reveals three potential catalytic active sites. Zhao Y, et al. Protein Sci, 2003 Oct. PMID 14500888, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Parkinsonism-associated protein DJ-1 and its bacterial homologs deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL function as deglycases that repair proteins and nucleotides from endogeneous glycation by glyoxal and methylglyoxal. DJ-1, deglycase 1 and deglycase 2 repair glyoxal- and methylglyoxal-glycated substrates, whereas deglycase 3 principally repairs glyoxal-glycated substrates.
      Title: Further characterization of the Maillard deglycase DJ-1 and its prokaryotic homologs, deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL.
    2. The authors found that Hsp31 displays glyoxalase activity that catalyses the conversion of methylglyoxal (MG) to d-lactate without an additional cofactor.
      Title: Hsp31 of Escherichia coli K-12 is glyoxalase III.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Function of the Escherichia coli nucleoid protein, H-NS: molecular analysis of a subset of proteins whose expression is enhanced in a hns deletion mutant.
    4. Study presents evidence for an additional, novel, temperature-dependent control of Hsp31 expression by increased transcript stability.
      Title: Thermoregulation of Escherichia coli hchA transcript stability.
    5. Hsp31, the hchA gene product, plays an important role in the acid resistance of starved Escherichia coli but that it has little influence on oxidative-stress survival
      Title: Chaperone Hsp31 contributes to acid resistance in stationary-phase Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glyoxalase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyoxalase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glyoxalase III activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein deglycase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein deglycase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiolester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within RNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within guanine deglycation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lactate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to methylglyoxal IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein/nucleic acid deglycase 1
    NP_416476.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2035835..2036686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416476.1 protein/nucleic acid deglycase 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416476.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7CSP7
      Conserved Domains (1) summary
      PRK04155
      Location:1 → 283
      PRK04155; protein deglycase HchA
    Nucleotide Protein
    Heading Accession and Version

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