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    mdtD putative multidrug efflux pump MdtD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946601, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mdtD
    Official Full Name
    putative multidrug efflux pump MdtD
    Primary source
    ECOCYC:EG12136
    Locus tag
    b2077
    See related
    ASAP:ABE-0006879
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2073; iceT; yegB
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG12136]. The YegB protein is an uncharacterised member of the major facilitator superfamily (MFS) of transporters . [More information is available at EcoCyc: EG12136].
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    Genomic context

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    Sequence:
    NC_000913.3 (2161464..2162879)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion protein MdtA Neighboring gene multidrug efflux pump RND permease subunit MdtB Neighboring gene multidrug efflux pump RND permease subunit MdtC Neighboring gene sensor histidine kinase BaeS Neighboring gene DNA-binding transcriptional activator BaeR Neighboring gene DUF1508 domain-containing protein YegP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel members of the two-component signal transduction genes in Escherichia coli. Nagasawa S, et al. J Biochem, 1993 Sep. PMID 8282725
    2. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. Baranova N, et al. J Bacteriol, 2002 Aug. PMID 12107134, Free PMC Article
    3. The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC. Nagakubo S, et al. J Bacteriol, 2002 Aug. PMID 12107133, Free PMC Article
    4. Analysis of a complete library of putative drug transporter genes in Escherichia coli. Nishino K, et al. J Bacteriol, 2001 Oct. PMID 11566977, Free PMC Article
    5. Microbial drug efflux proteins of the major facilitator superfamily. Saidijam M, et al. Curr Drug Targets, 2006 Jul. PMID 16842212

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative multidrug efflux pump MdtD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2161464..2162879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416581.1 putative multidrug efflux pump MdtD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416581.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376K501
      Conserved Domains (1) summary
      PRK10504
      Location:1 → 471
      PRK10504; putative transporter; Provisional
    Nucleotide Protein
    Heading Accession and Version

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