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    cirA iron-catecholate outer membrane transporter CirA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949042, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cirA
    Official Full Name
    iron-catecholate outer membrane transporter CirA
    Primary source
    ECOCYC:EG10155
    Locus tag
    b2155
    See related
    ASAP:ABE-0007126
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cir; ECK2148; feuA
    Summary
    Cir is a member of the Outer Membrane Receptor (OMR) family of porins. [More information is available at EcoCyc: EG10155].
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    Genomic context

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    Sequence:
    NC_000913.3 (2244778..2246769, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase 1 Neighboring gene S-formylglutathione hydrolase/S-lactoylglutathione hydrolase Neighboring gene lysine:H(+) symporter Neighboring gene DNA-binding transcriptional regulator YeiE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinate regulation by iron of the synthesis of phenolate compounds and three outer membrane proteins in Escherichia coli. McIntosh MA, et al. J Bacteriol, 1977 Jul. PMID 141448, Free PMC Article
    2. The colicin Ia receptor, Cir, is also the translocator for colicin Ia. Jakes KS, et al. Mol Microbiol, 2010 Feb. PMID 19919671, Free PMC Article
    3. Purification of the colicin I receptor. Bowles LK, et al. J Biol Chem, 1983 Jan 25. PMID 6337134
    4. Use of cir-lac operon fusions to study transcriptional regulation of the colicin Ia receptor in Escherichia coli K-12. Worsham PL, et al. J Bacteriol, 1981 Jan. PMID 7007329, Free PMC Article
    5. Antagonistic functions between the RNA chaperone Hfq and an sRNA regulate sensitivity to the antibiotic colicin. Salvail H, et al. EMBO J, 2013 Oct 16. PMID 24065131, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hfq acts as the repressor of cirA mRNA translation in the absence of sRNA.
      Title: Antagonistic functions between the RNA chaperone Hfq and an sRNA regulate sensitivity to the antibiotic colicin.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Cloning and promoter identification of the iron-regulated cir gene of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables colicin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables siderophore uptake transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables siderophore-iron transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bacteriocin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within siderophore transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siderophore-dependent iron import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of transmembrane transporter complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iron-catecholate outer membrane transporter CirA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2244778..2246769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416660.1 iron-catecholate outer membrane transporter CirA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416660.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YBA3
      Conserved Domains (1) summary
      PRK10064
      Location:1 → 663
      PRK10064; catecholate siderophore receptor CirA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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