tktB transketolase 2 [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: tktB
Official Full Name: transketolase 2
Primary source: ECOCYC:EG12100
Locus tag: b2465
See related: ASAP:ABE-0008117
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2460
Summary: Consistently co-purifies with the degradosome. [More information is available at EcoGene: EG12100]. TktB is responsible for the minor transketolase activity in Escherichia coli, and TktA is responsible for the major transketolase activity . [More information is available at EcoCyc: EG12100].
NEW: Try the new Gene table
Try the new Transcript table

NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

tktB is a transcriptional target of ppGpp; activation of tktB transcription by ppGpp occurs both through the modulation of RpoS levels and independent of RpoS.
Title: Synthetic growth phenotypes of Escherichia coli lacking ppGpp and transketolase A (tktA) are due to ppGpp-mediated transcriptional regulation of tktB.
stationary growth-dependent expression mediated by RpoS action
Title: RpoS-mediated growth-dependent expression of the Escherichia coli tkt genes encoding transketolases isoenzymes.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transketolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transketolase activity	IEA Inferred from Electronic Annotation more info
enables transketolase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in pentose-phosphate shunt	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pentose-phosphate shunt, non-oxidative branch	EXP Inferred from Experiment more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_416960.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain