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    pdxJ pyridoxine 5'-phosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947039, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pdxJ
    Official Full Name
    pyridoxine 5'-phosphate synthase
    Primary source
    ECOCYC:EG10693
    Locus tag
    b2564
    See related
    ASAP:ABE-0008435
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2562
    Summary
    Pyridoxine 5'-phosphate synthase is one of two key enzymes involved in the ring closure of the aromatic pyridoxin ring in vitamin B12 biosynthesis. [More information is available at EcoCyc: EG10693].
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    Genomic context

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    Sequence:
    NC_000913.3 (2700998..2701729, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene holo-[acyl-carrier-protein] synthase Neighboring gene recombination mediator protein RecO Neighboring gene 30S ribosomal subunit maturation GTPase Era Neighboring gene RNase III

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray crystallographic analysis of PdxJ, the pyridoxine 5'-phosphate synthesizing enzyme. Garrido Franco M, et al. Acta Crystallogr D Biol Crystallogr, 2000 Aug. PMID 10944349
    2. Structural basis for the function of pyridoxine 5'-phosphate synthase. Franco MG, et al. Structure, 2001 Mar 7. PMID 11286891
    3. Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis. Garrido-Franco M, et al. J Mol Biol, 2002 Aug 23. PMID 12206776
    4. Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate. Yeh JI, et al. Biochemistry, 2002 Oct 1. PMID 12269807
    5. Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12. Man TK, et al. J Bacteriol, 1996 Apr. PMID 8636054, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Locating essential Escherichia coli genes by using mini-Tn10 transposons: the pdxJ operon.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxine 5'-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxine 5'-phosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxine 5'-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring nitrogenous groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pyridoxine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyridoxine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyridoxine 5'-phosphate synthase
    NP_417059.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2700998..2701729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417059.1 pyridoxine 5'-phosphate synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417059.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8NCV9
      Conserved Domains (1) summary
      PRK05265
      Location:4 → 241
      PRK05265; pyridoxine 5'-phosphate synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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