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    mtgA peptidoglycan glycosyltransferase MtgA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947728, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mtgA
    Official Full Name
    peptidoglycan glycosyltransferase MtgA
    Primary source
    ECOCYC:G7668
    Locus tag
    b3208
    See related
    ASAP:ABE-0010530
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3197; mgt; yrbM
    Summary
    MtgA has flavomycin-resistant peptidoglycan synthesis activity (Di Berardino, 1996; Derouaux, 2007). mtgA is a non-essential gene (Schiffer, 1999). [More information is available at EcoGene: EG12808]. MtgA is a monofunctional peptidoglycan transglycosylase involved in polymerization of lipid II molecules into glycan strands of peptidoglycan. [More information is available at EcoCyc: G7668].
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    Genomic context

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    Sequence:
    NC_000913.3 (3349081..3349809, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphotransferase system enzyme IIA(Ntr) Neighboring gene RNase adaptor protein RapZ Neighboring gene phosphorelay protein NPr Neighboring gene protein kinase-like domain-containing protein YrbL Neighboring gene low activity glyoxalase ElbB Neighboring gene ncRNA Neighboring gene sensor histidine kinase ArcB Neighboring gene radical SAM family oxidoreductase YhcC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Killing by ampicillin and ofloxacin induces overlapping changes in Escherichia coli transcription profile. Kaldalu N, et al. Antimicrob Agents Chemother, 2004 Mar. PMID 14982780, Free PMC Article
    2. The monofunctional glycosyltransferase of Escherichia coli is a member of a new class of peptidoglycan-synthesising enzymes. Di Berardino M, et al. FEBS Lett, 1996 Aug 26. PMID 8772200
    3. A novel glycan polymerase that synthesizes uncross-linked peptidoglycan in Escherichia coli. Hara H, et al. FEBS Lett, 1984 Mar 12. PMID 6368264
    4. The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN. Derouaux A, et al. J Bacteriol, 2008 Mar. PMID 18165305, Free PMC Article
    5. Genomic changes arising in long-term stab cultures of Escherichia coli. Faure D, et al. J Bacteriol, 2004 Oct. PMID 15375124, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that MtgA localizes at the division site of Escherichia coli cells that are deficient in PBP1b and produce a thermosensitive PBP1a and is able to interact with three constituents of the divisome, PBP3, FtsW, and FtsN.
      Title: The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidoglycan glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidoglycan glycosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Gram-negative-bacterium-type cell wall biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peptidoglycan-based cell wall IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidoglycan glycosyltransferase MtgA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3349081..3349809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417675.1 peptidoglycan glycosyltransferase MtgA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417675.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TUH9
      Conserved Domains (1) summary
      PRK00056
      Location:5 → 239
      mtgA; monofunctional biosynthetic peptidoglycan transglycosylase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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