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    rplR 50S ribosomal subunit protein L18 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947804, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rplR
    Official Full Name
    50S ribosomal subunit protein L18
    Primary source
    ECOCYC:EG10879
    Locus tag
    b3304
    See related
    ASAP:ABE-0010825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3291
    Summary
    rplR is an essential gene as judged by the inability to recombineer haploid deletions (Baba, 2006; Korepanov, 2006). [More information is available at EcoGene: EG10879]. The L18 protein is a component of the 50S subunit of the ribosome and is required for incorporation of 5S rRNA into the ribosome . [More information is available at EcoCyc: EG10879].
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    Genomic context

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    Sequence:
    NC_000913.3 (3445244..3445597, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal subunit protein L30 Neighboring gene 30S ribosomal subunit protein S5 Neighboring gene 50S ribosomal subunit protein L6 Neighboring gene 30S ribosomal subunit protein S8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Iodination of Escherichia coli ribosomal protein L18 abolishes its 5 S RNA binding activity. Fanning TG, et al. Biochim Biophys Acta, 1981 Feb 26. PMID 7011398
    2. Importance of the 5 S rRNA-binding ribosomal proteins for cell viability and translation in Escherichia coli. Korepanov AP, et al. J Mol Biol, 2007 Mar 2. PMID 17198710, Free PMC Article
    3. Janus chaperones: assistance of both RNA- and protein-folding by ribosomal proteins. Kovacs D, et al. FEBS Lett, 2009 Jan 5. PMID 19071121
    4. Photoaffinity labeling of Escherichia coli ribosomes by an aryl azide analogue of puromycin. On the identification of the major covalently labeled ribosomal proteins and on the mechanism of photoincorporation. Nicholson AW, et al. Biochemistry, 1982 Aug 3. PMID 6753920
    5. Localization of sites of photoaffinity labeling of the large subunit of Escherichia coli ribosomes by arylazide derivative of puromycin. Olson HM, et al. J Biol Chem, 1985 Aug 25. PMID 3894368

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: A method for the chemical generation of N-terminal peptide sequence tags for rapid protein identification.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 5S rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5S rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    50S ribosomal subunit protein L18

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3445244..3445597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417763.1 50S ribosomal subunit protein L18 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417763.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9API8
      Conserved Domains (1) summary
      PRK05593
      Location:25 → 117
      rplR; 50S ribosomal protein L18; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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