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    pdeK c-di-GMP phosphodiesterase PdeK [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948048, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pdeK
    Official Full Name
    c-di-GMP phosphodiesterase PdeK
    Primary source
    ECOCYC:EG12256
    Locus tag
    b3529
    See related
    ASAP:ABE-0011533
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3514; yhjK
    Summary
    YhjK has a central GGDEF putative diguanylate cyclase, then a C-terminal putative cyclic-di-GMP phosphodiesterase EAL domain. [More information is available at EcoGene: EG12256]. YhjK is an inner membrane protein with three predicted transmembrane domains. [More information is available at EcoCyc: EG12256].
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    Genomic context

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    Sequence:
    NC_000913.3 (3683630..3685618, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidase M16 family protein YhjJ Neighboring gene C4 dicarboxylate/orotate:H(+) symporter Neighboring gene cellulose synthase outer membrane channel Neighboring gene endo-1,4-D-glucanase Neighboring gene cellulose synthase periplasmic subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Engineered allosteric ribozymes that sense the bacterial second messenger cyclic diguanosyl 5'-monophosphate. Gu H, et al. Anal Chem, 2012 Jun 5. PMID 22519888, Free PMC Article
    2. Local c-di-GMP Signaling in the Control of Synthesis of the E. coli Biofilm Exopolysaccharide pEtN-Cellulose. Richter AM, et al. J Mol Biol, 2020 Jul 24. PMID 32534064, Free PMC Article
    3. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609
    4. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833
    5. Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite chromatography. Fountoulakis M, et al. Electrophoresis, 1999 Aug. PMID 10493123

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cyclic-guanylate-specific phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclic-guanylate-specific phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic-guanylate-specific phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    c-di-GMP phosphodiesterase PdeK
    NP_417986.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3683630..3685618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417986.4 c-di-GMP phosphodiesterase PdeK [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417986.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAI9H062
      Conserved Domains (1) summary
      PRK13561
      Location:25 → 662
      PRK13561; putative diguanylate cyclase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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