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    mioC flavoprotein MioC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948249, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mioC
    Official Full Name
    flavoprotein MioC
    Primary source
    ECOCYC:EG11199
    Locus tag
    b3742
    See related
    ASAP:ABE-0012235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3736; yieB
    Summary
    DnaA regulon. [More information is available at EcoGene: EG11199]. MioC is a flavoprotein (FMN binding) that is necessary for activity of biotin synthase in an in vitro system . [More information is available at EcoCyc: EG11199].
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    Genomic context

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    Sequence:
    NC_000913.3 (3926012..3926455, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S rRNA m(7)G527 methyltransferase Neighboring gene 5-carboxymethylaminomethyluridine-tRNA synthase subunit MnmG Neighboring gene DNA-binding transcriptional dual regulator AsnC Neighboring gene asparagine synthetase A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MioC and GidA proteins promote cell division in E. coli. Lies M, et al. Front Microbiol, 2015. PMID 26074904, Free PMC Article
    2. Nucleotide sequence of the origin of replication of the Escherichia coli K-12 chromosome. Meijer M, et al. Proc Natl Acad Sci U S A, 1979 Feb. PMID 370833, Free PMC Article
    3. Solution structures and backbone dynamics of a flavodoxin MioC from Escherichia coli in both Apo- and Holo-forms: implications for cofactor binding and electron transfer. Hu Y, et al. J Biol Chem, 2006 Nov 17. PMID 16963438
    4. Different effects of mioC transcription on initiation of chromosomal and minichromosomal replication in Escherichia coli. Løbner-Olesen A, et al. Nucleic Acids Res, 1992 Jun 25. PMID 1620598, Free PMC Article
    5. Stability and replication control of Escherichia coli minichromosomes. Løbner-Olesen A, et al. J Bacteriol, 1987 Jun. PMID 3294807, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: MioC is an FMN-binding protein that is essential for Escherichia coli biotin synthase activity in vitro.
    2. The solution structures of both the apo- and holo-forms of E. coli MioC protein at high resolution by nuclear magnetic resonance spectroscopy are reported.
      Title: Solution structures and backbone dynamics of a flavodoxin MioC from Escherichia coli in both Apo- and Holo-forms: implications for cofactor binding and electron transfer.
    3. A new set of rules for identifying efficiently titrating DnaA box regions was formulated and used to analyse sequences in mioC promoter.
      Title: Sequence characteristics required for cooperative binding and efficient in vivo titration of the replication initiator protein DnaA in E. coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flavoprotein MioC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3926012..3926455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418198.1 flavoprotein MioC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418198.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L9FZL4
      Conserved Domains (1) summary
      PRK09004
      Location:1 → 146
      PRK09004; FMN-binding protein MioC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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