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    glnG DNA-binding transcriptional dual regulator NtrC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948361, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glnG
    Official Full Name
    DNA-binding transcriptional dual regulator NtrC
    Primary source
    ECOCYC:EG10385
    Locus tag
    b3868
    See related
    ASAP:ABE-0012632
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3861; glnT; ntrC
    Summary
    NtrC is a member of the 54-dependent activator family and belongs to the two-component system NtrB/NtrC . [More information is available at EcoCyc: EG10385].
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    Genomic context

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    Sequence:
    NC_000913.3 (4053869..4055278, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene coproporphyrinogen III dehydrogenase Neighboring gene uncharacterized protein YshB Neighboring gene protein histidine kinase NtrB Neighboring gene glutamine synthetase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for a second interaction between the regulatory amino-terminal and central output domains of the response regulator NtrC (nitrogen regulator I) in Escherichia coli. Harrod AC, et al. J Biol Chem, 2004 Jan 23. PMID 14563853
    2. Phosphorylation site of NtrC, a protein phosphatase whose covalent intermediate activates transcription. Sanders DA, et al. J Bacteriol, 1992 Aug. PMID 1321122, Free PMC Article
    3. Nitrogen and carbon status are integrated at the transcriptional level by the nitrogen regulator NtrC in vivo. Schumacher J, et al. mBio, 2013 Nov 19. PMID 24255125, Free PMC Article
    4. Phosphorylation of nitrogen regulator I of Escherichia coli induces strong cooperative binding to DNA essential for activation of transcription. Weiss V, et al. Proc Natl Acad Sci U S A, 1992 Jun 1. PMID 1350679, Free PMC Article
    5. Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA+ ATPase domains. Lee SY, et al. Genes Dev, 2003 Oct 15. PMID 14561776, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results reveal that nitrogen-starved Escherichia coli synthesizes (p)ppGpp and forms a higher percentage of persister cells than nonstarved cells and that both NtrC and RelA are important for these processes.
      Title: Nitrogen Starvation Induces Persister Cell Formation in Escherichia coli.
    2. Transcription of relA, a key gene responsible for the synthesis of ppGpp, is activated by NtrC during nitrogen starvation.
      Title: Nitrogen stress response and stringent response are coupled in Escherichia coli.
    3. Authors show that the dominant role of NtrC is to regulate glnA transcription and its own expression, indicating that the glutamine paradox is not due to NtrC-independent gene regulation.
      Title: Nitrogen and carbon status are integrated at the transcriptional level by the nitrogen regulator NtrC in vivo.
    4. Results determine a possible pathway of interconversion between the active state and the inactive state of nitrogen regulatory protein C by targeted molecular dynamics simulations.
      Title: Segmented transition pathway of the signaling protein nitrogen regulatory protein C.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorelay response regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nitrogen fixation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of nitrogen utilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator NtrC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4053869..4055278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418304.1 DNA-binding transcriptional dual regulator NtrC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418304.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H9XXD4
      Conserved Domains (1) summary
      PRK10923
      Location:1 → 469
      glnG; nitrogen regulation protein NR(I); Provisional
    Nucleotide Protein
    Heading Accession and Version

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