katG catalase/hydroperoxidase HPI [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: katG
Official Full Name: catalase/hydroperoxidase HPI
Primary source: ECOCYC:EG10511
Locus tag: b3942
See related: ASAP:ABE-0012901
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3934
Summary: With AhpCF, KatG protects aerobic, phosphate-starved cells from oxidative damage. [More information is available at EcoGene: EG10511]. The KatG enzyme is a bifunctional hydroperoxidase I, having both catalase and peroxidase activity. [More information is available at EcoCyc: EG10511].
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Genomic context

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Sequence:: NC_000913.3 (4133835..4136015)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sixteen mutations were identified in KatG linked to isoniazid resistance in Mycobacterium tuberculosis.
Title: Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.
Treatment of wild-type cells with proline significantly increased hydroperoxidase I (encoded by katG) expression and activity.
Title: Proline metabolism increases katG expression and oxidative stress resistance in Escherichia coli.
The quinone binding site modulates the electrochemical properties of heme b.
Title: Q-site occupancy defines heme heterogeneity in Escherichia coli nitrate reductase A (NarGHI).
peroxidase substrates have a central role in the unusual catalase mechanism of KatG
Title: Stimulation of KatG catalase activity by peroxidatic electron donors.
Data show that turnover and efficiency of peroxidase activity increases with decreasing pH until the protein unfolds.
Title: The kinetic properties producing the perfunctory pH profiles of catalase-peroxidases.
H2O2-inducible antioxidant defense system leading to an increase in HPI activity, is unaltered in Deltafur mutants
Title: Reduced hydroperoxidase (HPI and HPII) activity in the Deltafur mutant contributes to increased sensitivity to UVA radiation in Escherichia coli.
Hpx- (katG katE ahpCF) mutants of Escherichia coli have DNA damage from submicromolar intracellular hydrogen peroxide
Title: Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli.
X-ray crystallographic structure of the C-terminal domain of the catalase-peroxidase KatG from Escherichia coli
Title: Structure of the C-terminal domain of the catalase-peroxidase KatG from Escherichia coli.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables catalase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catalase activity	IDA Inferred from Direct Assay more info	PubMed
enables catalase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hydrogen peroxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: catalase/hydroperoxidase HPI

NP_418377.1

EC 1.11.1.21

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

4133835..4136015

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_418377.1 catalase/hydroperoxidase HPI [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_418377.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A6M9X119

Conserved Domains (1) summary

PRK15061
Location:11 → 725

PRK15061; catalase/peroxidase