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    frdA fumarate reductase flavoprotein subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948667, updated on 3-Dec-2024

    Summary

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    Official Symbol
    frdA
    Official Full Name
    fumarate reductase flavoprotein subunit
    Primary source
    ECOCYC:EG10330
    Locus tag
    b4154
    See related
    ASAP:ABE-0013604
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4150
    Summary
    frdA transcription is repressed by nitrate via the NarXL system. [More information is available at EcoGene: EG10330]. FrdA is one of two catalytic subunits in the four subunit enzyme. [More information is available at EcoCyc: EG10330].
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    Genomic context

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    Sequence:
    NC_000913.3 (4380510..4382318, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fumarate reductase membrane protein FrdD Neighboring gene fumarate reductase membrane protein FrdC Neighboring gene fumarate reductase iron-sulfur protein Neighboring gene EF-P-lysine lysyltransferase Neighboring gene putative transporter YjeM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fumarate reductase of Escherichia coli. Elucidation of the covalent-flavin component. Weiner JH, et al. J Biol Chem, 1979 Sep 10. PMID 381310
    2. Identification of active site residues of Escherichia coli fumarate reductase by site-directed mutagenesis. Schröder I, et al. J Biol Chem, 1991 Jul 25. PMID 1856194
    3. A metabolic enzyme that rapidly produces superoxide, fumarate reductase of Escherichia coli. Imlay JA. J Biol Chem, 1995 Aug 25. PMID 7649986
    4. Genetic and physical characterization of lambda transducing phages (lambda frdA) containing the fumarate reductase gene of Escherichia coli K12. Cole ST, et al. Mol Gen Genet, 1980. PMID 6446651
    5. Location and nucleotide sequence of frdB, the gene coding for the iron-sulphur protein subunit of the fumarate reductase of Escherichia coli. Cole ST, et al. Eur J Biochem, 1982 Aug. PMID 6751816

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We demonstrate that the FAD assembly factor SdhE, which flavinylates and activates the respiratory enzyme succinate dehydrogenase (SDH), is also required for the complete activation and flavinylation of fumarate reductase .
      Title: The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria.
    2. structural and catalytic analyses of the FrdA E49Q and SdhA Q50E mutants suggest that coulombic effects and the electronic state of the FAD are critical for directionality of the succinate/fumarate interconversions
      Title: Fumarate reductase and succinate oxidase activity of Escherichia coli complex II homologs are perturbed differently by mutation of the flavin binding domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FAD binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables succinate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in anaerobic electron transport chain NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in anaerobic respiration EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in anaerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaerobic respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anaerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bacterial-type flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fermentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fermentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of fumarate reductase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of fumarate reductase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fumarate reductase flavoprotein subunit
    NP_418578.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4380510..4382318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418578.1 fumarate reductase flavoprotein subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418578.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3K0WAP0, A0A8S7CWC2
      Conserved Domains (1) summary
      PRK09231
      Location:2 → 583
      PRK09231; fumarate reductase flavoprotein subunit; Validated
    Nucleotide Protein
    Heading Accession and Version

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