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    tsaE N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948684, updated on 17-Dec-2024

    Summary

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    Official Symbol
    tsaE
    Official Full Name
    N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit
    Primary source
    ECOCYC:EG11757
    Locus tag
    b4168
    See related
    ASAP:ABE-0013649
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4164; yjeE
    Summary
    yjeE is non-essential in the presence of multicopy rstA (Campbell, 2007). [More information is available at EcoGene: EG11757]. YjeE is essential for growth in complex media . [More information is available at EcoCyc: EG11757].
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    Genomic context

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    Sequence:
    NC_000913.3 (4395585..4396046)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene uncharacterized protein YjeV Neighboring gene epoxyqueuosine reductase Neighboring gene NAD(P)HX epimerase/NAD(P)HX dehydratase Neighboring gene N-acetylmuramoyl-L-alanine amidase B Neighboring gene DNA mismatch repair protein MutL Neighboring gene tRNA dimethylallyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing the active site of YjeE: a vital Escherichia coli protein of unknown function. Allali-Hassani A, et al. Biochem J, 2004 Dec 15. PMID 15324301, Free PMC Article
    2. Known bioactive small molecules probe the function of a widely conserved but enigmatic bacterial ATPase, YjeE. Mangat CS, et al. Chem Biol, 2008 Dec 22. PMID 19101473
    3. The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli. Zhang W, et al. Nucleic Acids Res, 2015 Feb 18. PMID 25578970, Free PMC Article
    4. Isolation of the rstA gene as a multicopy suppressor of YjeE, an essential ATPase of unknown function in Escherichia coli. Campbell TL, et al. J Bacteriol, 2007 Apr. PMID 17293428, Free PMC Article
    5. The ATPase activity of an 'essential' Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization. Karst JC, et al. Microbiology (Reading), 2009 Mar. PMID 19246765

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of translational fidelity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA threonylcarbamoyladenosine modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA threonylcarbamoyladenosine modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA threonylcarbamoyladenosine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit
    NP_418589.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4395585..4396046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418589.1 N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418589.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3ETE2, A0A0H3Q2Z2, A0A1D7PTI0, A0A377ATL9, A0A5B9ALY2, A0A8E0KSJ5, A0AAN3IMJ0, A0AAN3V1L9, A0AAN4NP42, B1LQI8
      Conserved Domains (1) summary
      PRK10646
      Location:1 → 153
      PRK10646; tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE
    Nucleotide Protein
    Heading Accession and Version

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