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    nsrR DNA-binding transcriptional regulator NsrR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948693, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nsrR
    Official Full Name
    DNA-binding transcriptional regulator NsrR
    Primary source
    ECOCYC:EG11212
    Locus tag
    b4178
    See related
    ASAP:ABE-0013676
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4174; yjeB
    Summary
    NsrR is a weak regulator of tehA. tehA clones may titrate out NsrR. [More information is available at EcoGene: EG11212]. NsrR , the "nitrite-sensitive repressor" , regulates genes involved in cell protection against nitric oxide (NO) . [More information is available at EcoCyc: EG11212].
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    Genomic context

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    Sequence:
    NC_000913.3 (4406190..4406615)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2065 domain-containing protein YjeT Neighboring gene adenylosuccinate synthetase Neighboring gene RNase R Neighboring gene 23S rRNA 2'-O-ribose G2251 methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inefficient translation of nsrR constrains behaviour of the NsrR regulon in Escherichia coli. Chhabra S, et al. Microbiology (Reading), 2015 Oct. PMID 26239124
    2. Expression of nitrite reductase in Nitrosomonas europaea involves NsrR, a novel nitrite-sensitive transcription repressor. Beaumont HJ, et al. Mol Microbiol, 2004 Oct. PMID 15458412
    3. The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster. Tucker NP, et al. PLoS One, 2008. PMID 18989365, Free PMC Article
    4. In vivo [Fe-S] cluster acquisition by IscR and NsrR, two stress regulators in Escherichia coli. Vinella D, et al. Mol Microbiol, 2013 Feb. PMID 23320508
    5. Down-regulation of the Escherichia coli K-12 nrf promoter by binding of the NsrR nitric oxide-sensing transcription repressor to an upstream site. Browning DF, et al. J Bacteriol, 2010 Jul. PMID 20472787, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors show that nsrR is expressed from a strong promoter, but that its translation is extremely inefficient, leading to a low cellular NsrR concentration.
      Title: Inefficient translation of nsrR constrains behaviour of the NsrR regulon in Escherichia coli.
    2. Fe-S clusters directed at the apo-NsrR and apo-IscR proteins are built on either of the two scaffolds, IscU or SufB.
      Title: In vivo [Fe-S] cluster acquisition by IscR and NsrR, two stress regulators in Escherichia coli.
    3. Activation of the Escherichia coli K-12 nrf promoter is downregulated by the nitric oxide-sensitive NsrR protein together with the nucleoid-associated protein IHF.
      Title: Down-regulation of the Escherichia coli K-12 nrf promoter by binding of the NsrR nitric oxide-sensing transcription repressor to an upstream site.
    4. NsrR is a negative regulator of motility in E. coli K12.
      Title: NsrR targets in the Escherichia coli genome: new insights into DNA sequence requirements for binding and a role for NsrR in the regulation of motility.
    5. Suppression of growth defects in E coli lacking phosphorolytic ribonnucleases was found to be controlled by nrR, a nitric oxide (NO)-sensitive transcriptional repressor.
      Title: Identification and characterization of growth suppressors of Escherichia coli strains lacking phosphorolytic ribonucleases.
    6. Overexpression of NsrR represses the tynA and feaB promoters and severely retards growth on phenylethylamine.
      Title: Escherichia coli NsrR regulates a pathway for the oxidation of 3-nitrotyramine to 4-hydroxy-3-nitrophenylacetate.
    7. Identification of binding sites for the nitric oxide-sensitive transcriptional regulator NsrR.
      Title: Genome-wide identification of binding sites for the nitric oxide-sensitive transcriptional regulator NsrR.
    8. NsrR represses the hybrid cluster protein, HCP, and nrfA promoter that directs the expression of the periplasmic respiratory nitrite reductase.
      Title: The NsrR regulon of Escherichia coli K-12 includes genes encoding the hybrid cluster protein and the periplasmic, respiratory nitrite reductase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional regulator NsrR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4406190..4406615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418599.1 DNA-binding transcriptional regulator NsrR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418599.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0G4A2
      Conserved Domains (1) summary
      PRK11014
      Location:1 → 141
      PRK11014; HTH-type transcriptional repressor NsrR
    Nucleotide Protein
    Heading Accession and Version

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