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    cysB DNA-binding transcriptional dual regulator CysB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945771, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cysB
    Official Full Name
    DNA-binding transcriptional dual regulator CysB
    Primary source
    ECOCYC:EG10184
    Locus tag
    b1275
    See related
    ASAP:ABE-0004279
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1269
    Summary
    LysR family. [More information is available at EcoGene: EG10184]. This protein controls the expression of the cysteine regulon (cysB, cysDNC, cysJIH, cysPUWAM, and cysK) that is a system of 10 or more loci involved in the biosynthesis of L-cysteine. [More information is available at EcoCyc: EG10184].
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    Genomic context

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    Sequence:
    NC_000913.3 (1333855..1334829)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YciN Neighboring gene DNA topoisomerase 1 Neighboring gene uncharacterized protein YmiA Neighboring gene uncharacterized protein YciX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Structure of the LysR-type Transcriptional Regulator, CysB, Bound to the Inducer, N-acetylserine. Verschueren KHG, et al. Eur Biophys J, 2024 Aug. PMID 38976018, Free PMC Article
    2. The molecular basis for positive regulation of cys promoters in Salmonella typhimurium and Escherichia coli. Kredich NM. Mol Microbiol, 1992 Oct. PMID 1435253
    3. Analysis of the Escherichia coli K-12 cysB gene and its product using the method of gene fusion. Tei H, et al. Biochem Biophys Res Commun, 1990 Mar 30. PMID 2182030
    4. In vitro interactions of CysB protein with the cysK and cysJIH promoter regions of Salmonella typhimurium. Monroe RS, et al. J Bacteriol, 1990 Dec. PMID 2254265, Free PMC Article
    5. Effect of DNA gyrase inhibitors and urea on the expression of cysB, the regulatory gene of the cysteine regulon. Bielińska A, et al. J Gen Microbiol, 1986 Sep. PMID 2432161

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Structure of the LysR-type Transcriptional Regulator, CysB, Bound to the Inducer, N-acetylserine.
      Title: The Structure of the LysR-type Transcriptional Regulator, CysB, Bound to the Inducer, N-acetylserine.
    2. Upregulation of PBP1B and LpoB in cysB mutants confers mecillinam resistance in Escherichia coli.
      Title: Upregulation of PBP1B and LpoB in cysB Mutants Confers Mecillinam (Amdinocillin) Resistance in Escherichia coli.
    3. N-terminus verified by Edman degradation on complete protein
      Title: Analysis of the Escherichia coli K-12 cysB gene and its product using the method of gene fusion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in cysteine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator CysB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1333855..1334829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415791.1 DNA-binding transcriptional dual regulator CysB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415791.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0B5HIE8, A0A0B5HL80, A0A828PKS6, A0A8S7RWM5
      Conserved Domains (1) summary
      PRK12681
      Location:1 → 324
      cysB; HTH-type transcriptional regulator CysB
    Nucleotide Protein
    Heading Accession and Version

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