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    malI DNA-binding transcriptional repressor MalI [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947104, updated on 3-Dec-2024

    Summary

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    Official Symbol
    malI
    Official Full Name
    DNA-binding transcriptional repressor MalI
    Primary source
    ECOCYC:EG10557
    Locus tag
    b1620
    See related
    ASAP:ABE-0005421
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1615
    Summary
    "Maltose inhibitor," MalI, is a repressor that controls genes related to the maltose system. [More information is available at EcoCyc: EG10557].
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    Genomic context

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    Sequence:
    NC_000913.3 (1698152..1699180, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor UidR Neighboring gene 7-alpha-hydroxysteroid dehydrogenase Neighboring gene PTS enzyme IIBC component MalX Neighboring gene negative regulator of MalT activity/cystathionine beta-lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targets for the MalI repressor at the divergent Escherichia coli K-12 malX-malI promoters. Lloyd GS, et al. FEMS Microbiol Lett, 2010 Apr. PMID 20141531
    2. Adaptive prediction of environmental changes by microorganisms. Mitchell A, et al. Nature, 2009 Jul 9. PMID 19536156
    3. Transcription initiation in the Escherichia coli K-12 malI-malX intergenic region and the role of the cyclic AMP receptor protein. Lloyd GS, et al. FEMS Microbiol Lett, 2008 Nov. PMID 19054084
    4. Identification of endogenous inducers of the mal regulon in Escherichia coli. Ehrmann M, et al. J Bacteriol, 1987 Aug. PMID 3038842, Free PMC Article
    5. MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI. Reidl J, et al. J Bacteriol, 1989 Sep. PMID 2670898, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The malI promoter is repressed by MalI binding from position +3 to position +18, downstream of the malI transcript start.
      Title: Targets for the MalI repressor at the divergent Escherichia coli K-12 malX-malI promoters.
    2. The malI promoter drives transcription initiation from a location 85 bp upstream from the malX transcript start and it is active without the CRP. Expression from the malI promoter can be stimulated by the CRP.
      Title: Transcription initiation in the Escherichia coli K-12 malI-malX intergenic region and the role of the cyclic AMP receptor protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-DNA complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor MalI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1698152..1699180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416137.1 DNA-binding transcriptional repressor MalI [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416137.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7CKF0
      Conserved Domains (1) summary
      PRK10014
      Location:1 → 342
      PRK10014; DNA-binding transcriptional repressor MalI; Provisional
    Nucleotide Protein
    Heading Accession and Version

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