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    mliC inhibitor of c-type lysozyme, putative lipoprotein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946811, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mliC
    Official Full Name
    inhibitor of c-type lysozyme, putative lipoprotein
    Primary source
    ECOCYC:EG11488
    Locus tag
    b1639
    See related
    ASAP:ABE-0005485
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1635; ydhA
    Summary
    MliC is membrane-bound, consistent with the prediction that it is a lipoprotein (Callewaert, 2008). mliC is in the Rcs regulon (Callewaert, 2009). [More information is available at EcoGene: EG11488]. The MliC protein inhibits activity of c-type lysozyme in vitro. [More information is available at EcoCyc: EG11488].
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    Genomic context

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    Sequence:
    NC_000913.3 (1718066..1718395, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tyrosine--tRNA ligase Neighboring gene pyridoxine/pyridoxamine 5'-phosphate oxidase Neighboring gene anhydro-N-acetylmuramic acid kinase Neighboring gene outer membrane lipoprotein SlyB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations. Lam HM, et al. J Bacteriol, 1992 Oct. PMID 1356963, Free PMC Article
    2. The Rcs two-component system regulates expression of lysozyme inhibitors and is induced by exposure to lysozyme. Callewaert L, et al. J Bacteriol, 2009 Mar. PMID 19136591, Free PMC Article
    3. The solution structure of the protein ydhA from Escherichia coli. Revington M, et al. J Biomol NMR, 2006 Aug. PMID 16937244
    4. A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. Aiba H, et al. DNA Res, 1996 Dec 31. PMID 9097039
    5. Prediction of lipoprotein signal peptides in Gram-negative bacteria. Juncker AS, et al. Protein Sci, 2003 Aug. PMID 12876315, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RcsB and RcsF two-component system regulates expression of lysozyme inhibitors, Ivy and MliC.
      Title: The Rcs two-component system regulates expression of lysozyme inhibitors and is induced by exposure to lysozyme.
    2. The solution structure of ydhA as a slghtly flattened eight stranded beta-barrel that is stabilized by an intramolecular disulfide bond, is reported.
      Title: The solution structure of the protein ydhA from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lysozyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic side of cell outer membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of c-type lysozyme, putative lipoprotein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1718066..1718395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416156.4 inhibitor of c-type lysozyme, putative lipoprotein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416156.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7I6H6W3, W8T169
      Conserved Domains (1) summary
      PRK11372
      Location:1 → 109
      PRK11372; C-type lysozyme inhibitor
    Nucleotide Protein
    Heading Accession and Version

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