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    sodC superoxide dismutase (Cu-Zn) [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945343, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sodC
    Official Full Name
    superoxide dismutase (Cu-Zn)
    Primary source
    ECOCYC:G6886
    Locus tag
    b1646
    See related
    ASAP:ABE-0005505
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1642
    Summary
    SodC is repressed anaerobically by Fnr and is induced in stationary phase by RpoS. [More information is available at EcoGene: EG13419]. SodC is a periplasmic enzyme that converts superoxide radicals to hydrogen peroxide and water. [More information is available at EcoCyc: G6886].
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    Genomic context

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    Sequence:
    NC_000913.3 (1724134..1724655, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative membrane fusion protein YdhJ Neighboring gene putative transporter YdhK Neighboring gene putative oxidoreductase YdhF Neighboring gene DUF1289 domain-containing protein YdhL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The regulation and role of the periplasmic copper, zinc superoxide dismutase of Escherichia coli. Gort AS, et al. Mol Microbiol, 1999 Apr. PMID 10216871
    2. Isolation of a new copper-containing superoxide dismutase bacteriocuprein. Puget K, et al. Biochem Biophys Res Commun, 1974 Jun 4. PMID 4836277
    3. Isolation of an active and heat-stable monomeric form of Cu,Zn superoxide dismutase from the periplasmic space of Escherichia coli. Battistoni A, et al. FEBS Lett, 1995 Oct 30. PMID 7589534
    4. Copper, zinc superoxide dismutase in Escherichia coli: periplasmic localization. Benov L, et al. Arch Biochem Biophys, 1995 Jun 1. PMID 7786035
    5. Escherichia coli expresses a copper- and zinc-containing superoxide dismutase. Benov LT, et al. J Biol Chem, 1994 Oct 14. PMID 7929223

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of the three SodCs is not redundant in biofilm formation and the resistance to oxidative damage.
      Title: A study on prophagic and chromosomal sodC genes involvement in Escherichia coli O157:H7 biofilm formation and biofilm resistance to H2O2.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide dismutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in removal of superoxide radicals IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within superoxide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    superoxide dismutase (Cu-Zn)
    NP_416163.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1724134..1724655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416163.1 superoxide dismutase (Cu-Zn) [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416163.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GBM9, A0A376LNG2, A0A7D7KFC7, B1AEH5
      Conserved Domains (1) summary
      PRK10290
      Location:1 → 173
      PRK10290; superoxide dismutase [Cu-Zn] SodC2
    Nucleotide Protein
    Heading Accession and Version

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