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    qseB DNA-binding transcriptional activator QseB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945369, updated on 3-Dec-2024

    Summary

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    Official Symbol
    qseB
    Official Full Name
    DNA-binding transcriptional activator QseB
    Primary source
    ECOCYC:G7575
    Locus tag
    b3025
    See related
    ASAP:ABE-0009936
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3016; ygiX
    Summary
    QseB, "quorum-sensing Escherichia coli regulator B", is the response regulator component of the QseB-QseC two-component system, which is one component of the quorum-sensing regulatory cascade involved in the positive regulation of flagella and motility genes by activating transcription of flhDC, an operon that encodes the master regulator of these genes . [More information is available at EcoCyc: G7575].
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    Genomic context

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    Sequence:
    NC_000913.3 (3169828..3170487)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor YgiV Neighboring gene BOF family protein YgiW Neighboring gene sensor histidine kinase QseC Neighboring gene DUF2645 domain-containing inner membrane protein YgiZ Neighboring gene NADPH:quinone oxidoreductase MdaB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nanoalumina triggers the antibiotic persistence of Escherichia coli through quorum sensing regulators lrsF and qseB. Wang S, et al. J Hazard Mater, 2022 Aug 15. PMID 35739728
    2. The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility. Wu D, et al. Gene, 2021 Mar 20. PMID 33359126
    3. Escherichia coli O157:H7 lacking the qseBC-encoded quorum-sensing system outcompetes the parental strain in colonization of cattle intestines. Sharma VK, et al. Appl Environ Microbiol, 2014 Mar. PMID 24413602, Free PMC Article
    4. QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli. Kostakioti M, et al. Mol Microbiol, 2009 Sep. PMID 19703104, Free PMC Article
    5. Transcriptional autoregulation by quorum sensing Escherichia coli regulators B and C (QseBC) in enterohaemorrhagic E. coli (EHEC). Clarke MB, et al. Mol Microbiol, 2005 Oct. PMID 16194231

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nanoalumina triggers the antibiotic persistence of Escherichia coli through quorum sensing regulators lrsF and qseB.
      Title: Nanoalumina triggers the antibiotic persistence of Escherichia coli through quorum sensing regulators lrsF and qseB.
    2. The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility.
      Title: The Escherichia coli QseB/QseC signaling is required for correct timing of replication initiation and cell motility.
    3. study concludes that cross talk between the regulatory systems for virulence and metabolism of aromatic amines may depend upon the ability of QseBC and, to a lesser extent QseF, to regulate feaR as well as genes directly involved in virulence
      Title: Conversion of Norepinephrine to 3,4-Dihdroxymandelic Acid in Escherichia coli Requires the QseBC Quorum-Sensing System and the FeaR Transcription Factor.
    4. All components of the QseBC and PmrAB two-component systems (TCSs) are required for proper response to ferric iron.
      Title: Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli.
    5. The presence of one sensor kinase, QseC, is required to regulate the interaction between the other sensor kinase, PmrB and the response regulators from both systems, QseB and PmrA, effectively creating a "four-component" system required for virulence.
      Title: The Histidine Residue of QseC Is Required for Canonical Signaling between QseB and PmrB in Uropathogenic Escherichia coli.
    6. Near-parental level of motility, ability to respond to norepinephrine, and enhanced expression of locus of enterocyte effacement and curli genes might in part be responsible for increased colonization and fecal shedding of the qseBC mutant in calves.
      Title: Escherichia coli O157:H7 lacking the qseBC-encoded quorum-sensing system outcompetes the parental strain in colonization of cattle intestines.
    7. The authors discovered that QseC has phosphatase activity required for QseB dephosphorylation.
      Title: QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay response regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to metal ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator QseB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3169828..3170487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417497.1 DNA-binding transcriptional activator QseB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417497.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3LG67
      Conserved Domains (1) summary
      PRK10336
      Location:1 → 219
      PRK10336; two-component system response regulator QseB
    Nucleotide Protein
    Heading Accession and Version

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