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    garL alpha-dehydro-beta-deoxy-D-glucarate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947630, updated on 3-Dec-2024

    Summary

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    Official Symbol
    garL
    Official Full Name
    alpha-dehydro-beta-deoxy-D-glucarate aldolase
    Primary source
    ECOCYC:EG10016
    Locus tag
    b3126
    See related
    ASAP:ABE-0010276
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3114; yhaF
    Summary
    dehydro--deoxy-D-glucarate aldolase cleaves both 5-dehydro-4-deoxy- and 2-dehydro-3-deoxy-D-glucarate, thereby continuing the catabolism of D-glucarate and D-galactarate . [More information is available at EcoCyc: EG10016].
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    Genomic context

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    Sequence:
    NC_000913.3 (3272787..3273557, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycerate 2-kinase 1 Neighboring gene tartronate semialdehyde reductase Neighboring gene galactarate/D-glucarate transporter GarP Neighboring gene GarD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rhombohedral crystals of 2-dehydro-3-deoxygalactarate aldolase from Escherichia coli. Blackwell NC, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jul. PMID 10393309
    2. Two genes affecting glucarate utilization in Escherichia coli K12. Roberton AM, et al. J Gen Microbiol, 1980 Apr. PMID 6999115
    3. Precise mapping of the rnpB gene encoding the RNA component of RNase P in Escherichia coli K-12. Komine Y, et al. J Bacteriol, 1991 Mar. PMID 1705543, Free PMC Article
    4. Processing of the precursor to the catalytic RNA subunit of RNase P from Escherichia coli. Lundberg U, et al. RNA, 1995 May. PMID 7489504, Free PMC Article
    5. Crystal structures of the metal-dependent 2-dehydro-3-deoxy-galactarate aldolase suggest a novel reaction mechanism. Izard T, et al. EMBO J, 2000 Aug 1. PMID 10921867, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-dehydro-3-deoxy-D-gluconate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-dehydro-3-deoxyglucarate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-dehydro-3-deoxyglucarate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbon-carbon lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-glucarate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-glucarate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within galactarate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in galactarate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glucarate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucarate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-dehydro-beta-deoxy-D-glucarate aldolase
    NP_417595.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3272787..3273557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417595.1 alpha-dehydro-beta-deoxy-D-glucarate aldolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417595.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376WX81, A0A6M9X3F9
      Conserved Domains (1) summary
      PRK10558
      Location:1 → 256
      PRK10558; alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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