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    mdtF multidrug efflux pump RND permease MdtF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948030, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mdtF
    Official Full Name
    multidrug efflux pump RND permease MdtF
    Primary source
    ECOCYC:EG12241
    Locus tag
    b3514
    See related
    ASAP:ABE-0011480
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3498; yhiV
    Summary
    EvgAS regulon. [More information is available at EcoGene: EG12241]. MdtF is a component of the MdtEF multidrug transporter. [More information is available at EcoCyc: EG12241].
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    Genomic context

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    Sequence:
    NC_000913.3 (3660414..3663527)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene multidrug efflux pump membrane fusion protein MdtE Neighboring gene DNA-binding transcriptional dual regulator GadW Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF). Bohnert JA, et al. J Antimicrob Chemother, 2007 Jun. PMID 17062614
    2. Role of the AraC-XylS family regulator YdeO in multi-drug resistance of Escherichia coli. Nishino K, et al. J Antibiot (Tokyo), 2009 May. PMID 19329985
    3. Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams. Nishino K, et al. Antimicrob Agents Chemother, 2003 Sep. PMID 12937021, Free PMC Article
    4. Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12. Schaffner SH, et al. Appl Environ Microbiol, 2021 Jul 27. PMID 34085861, Free PMC Article
    5. CRP regulator modulates multidrug resistance of Escherichia coli by repressing the mdtEF multidrug efflux genes. Nishino K, et al. J Antibiot (Tokyo), 2008 Mar. PMID 18503189

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12.
      Title: Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12.
    2. GadX increases multidrug resistance in E. coli through activation of the MdtEF efflux pump.
      Title: The AraC-family regulator GadX enhances multidrug resistance in Escherichia coli by activating expression of mdtEF multidrug efflux genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables efflux transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xenobiotic transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bile acid and bile salt transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xenobiotic transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multidrug efflux pump RND permease MdtF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3660414..3663527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417971.1 multidrug efflux pump RND permease MdtF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417971.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FUZ1, A0A793GLF9, A0A8S7I1T5
      Conserved Domains (1) summary
      PRK15127
      Location:1 → 1018
      PRK15127; multidrug efflux RND transporter permease subunit AcrB
    Nucleotide Protein
    Heading Accession and Version

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