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    lldD L-lactate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948121, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lldD
    Official Full Name
    L-lactate dehydrogenase
    Primary source
    ECOCYC:EG11963
    Locus tag
    b3605
    See related
    ASAP:ABE-0011784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3595; lct; lctD
    Summary
    Arc regulon. [More information is available at EcoGene: EG11963]. L-lactate dehydrogenase is an FMN-dependent membrane-associated dehydrogenase . [More information is available at EcoCyc: EG11963].
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    Genomic context

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    Sequence:
    NC_000913.3 (3779827..3781017)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2810 domain-containing protein YibL Neighboring gene lactate/glycolate:H(+) symporter LldP Neighboring gene DNA-binding transcriptional dual regulator LldR Neighboring gene tRNA (cytidine/uridine-2'-O)-ribose methyltransferase Neighboring gene serine acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Limiting availability of binding sites for dehydrogenases on the cell membrane of Escherichia coli. Kung HF, et al. Proc Natl Acad Sci U S A, 1972 Apr. PMID 4554536, Free PMC Article
    2. Effects of phospholipids on L-lactate dehydrogenase from membranes of Escherichia coli. Activation and stabilization of the enzyme with phospholipids. Kimura H, et al. J Biol Chem, 1978 Feb 25. PMID 342518
    3. Evolution of L-1, 2-propanediol catabolism in Escherichia coli by recruitment of enzymes for L-fucose and L-lactate metabolism. Cocks GT, et al. J Bacteriol, 1974 Apr. PMID 4595205, Free PMC Article
    4. Mechanisms of active transport in isolated bacterial membrane vesicles. X. Inactivation of D-lactate dehydrogenase and D-lactate dehydrogenase-coupled transport in Escherichia coli membrane vesicles by an acetylenic substrate. Walsh CT, et al. J Biol Chem, 1972 Dec 25. PMID 4565667
    5. Inducible membrane-bound L-lactate dehydrogenase from Escherichia coli. Purification and properties. Futai M, et al. J Biol Chem, 1977 Aug 25. PMID 18473

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results are consistent with the hypothesis that LldR has a dual role, acting as a repressor or an activator of lldPRD operon.
      Title: Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lactate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lactate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-fucose catabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aerobic respiration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in lactate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    L-lactate dehydrogenase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3779827..3781017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418062.1 L-lactate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418062.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MKZ5, A0A797I3W7
      Conserved Domains (1) summary
      PRK11197
      Location:1 → 380
      lldD; L-lactate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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