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    fdoG formate dehydrogenase O subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948394, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fdoG
    Official Full Name
    formate dehydrogenase O subunit alpha
    Primary source
    ECOCYC:EG11858
    Locus tag
    b3894
    See related
    ASAP:ABE-0012710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3887
    Summary
    Also known as FDH-Z. [More information is available at EcoGene: EG11858]. By similarity to the paralogous subunit of formate dehydrogenase-N, FdnG, FdoG is thought to be the catalytic subunit of formate dehydrogenase-O, containing the bis-molybdopterin guanine dinucleotide (MGD) cofactor and selenocysteine . [More information is available at EcoCyc: EG11858].
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    Genomic context

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    Sequence:
    NC_000913.3 (4082772..4085822, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene formate dehydrogenase formation protein Neighboring gene formate dehydrogenase O subunit gamma Neighboring gene formate dehydrogenase O subunit beta Neighboring gene sulfurtransferase for molybdenum cofactor sulfuration Neighboring gene DUF3829 domain-containing lipoprotein YiiG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes. Zhang Y, et al. Bioinformatics, 2005 Jun 1. PMID 15797911
    2. SECISDesign: a server to design SECIS-elements within the coding sequence. Busch A, et al. Bioinformatics, 2005 Aug 1. PMID 15919727
    3. Formate protects stationary-phase Escherichia coli and Salmonella cells from killing by a cationic antimicrobial peptide. Barker HC, et al. Mol Microbiol, 2000 Mar. PMID 10760151
    4. Expression and operon structure of the sel genes of Escherichia coli and identification of a third selenium-containing formate dehydrogenase isoenzyme. Sawers G, et al. J Bacteriol, 1991 Aug. PMID 1650339, Free PMC Article
    5. Comparing system-specific chaperone interactions with their Tat dependent redox enzyme substrates. Chan CS, et al. FEBS Lett, 2010 Nov 19. PMID 20974141, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formate dehydrogenase (cytochrome-c-553) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formate dehydrogenase (quinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdopterin cofactor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in anaerobic electron transport chain NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within anaerobic respiration EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in anaerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular respiration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within formate oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in formate oxidation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heme oxidation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of formate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of formate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane HDA PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    formate dehydrogenase O subunit alpha
    NP_418330.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4082772..4085822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418330.1 formate dehydrogenase O subunit alpha [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418330.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A3BVK2, D3H526
      Conserved Domains (1) summary
      cl09928
      Location:2 → 1015
      Molybdopterin-Binding; Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and ...
    Nucleotide Protein
    Heading Accession and Version

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