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    pfkA 6-phosphofructokinase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948412, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pfkA
    Official Full Name
    6-phosphofructokinase 1
    Primary source
    ECOCYC:EG10699
    Locus tag
    b3916
    See related
    ASAP:ABE-0012789
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3908
    Summary
    This enzyme is an isozyme with phosphofructokinase-2. [More information is available at EcoCyc: EG10699].
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    Genomic context

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    Sequence:
    NC_000913.3 (4107552..4108514)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter Neighboring gene sulfate/thiosulfate ABC transporter periplasmic binding protein Sbp Neighboring gene CDP-diacylglycerol diphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Glu187 in the regulation of phosphofructokinase by phosphoenolpyruvate. Auzat I, et al. J Mol Biol, 1994 Jan 7. PMID 7904653
    2. Persistent binding of MgADP to the E187A mutant of Escherichia coli phosphofructokinase in the absence of allosteric effects. Pham AS, et al. Biochemistry, 2001 Apr 3. PMID 11300795
    3. Reaction path of phosphofructo-1-kinase is altered by mutagenesis and alternative substrates. Wang X, et al. Biochemistry, 2001 Apr 3. PMID 11300773
    4. Crystal structure of unliganded phosphofructokinase from Escherichia coli. Rypniewski WR, et al. J Mol Biol, 1989 Jun 20. PMID 2527305
    5. Urea-induced inactivation, dissociation, and unfolding of the allosteric phosphofructokinase from Escherichia coli. Bras GL, et al. Biochemistry, 1989 Aug 22. PMID 2531001

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. All four unique heterotropic interactions between phosphoenolpyruvate and fructose 6-phosphate contributed to the inhibition of pfkA.
      Title: Disentangling the web of allosteric communication in a homotetramer: heterotropic inhibition in phosphofructokinase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 6-phosphofructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 6-phosphofructokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 6-phosphofructokinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose-6-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical glycolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glucose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycolytic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 6-phosphofructokinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of 6-phosphofructokinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    6-phosphofructokinase 1
    NP_418351.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4107552..4108514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418351.1 6-phosphofructokinase 1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418351.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9Q859, A0A7A2XQR7
      Conserved Domains (1) summary
      PRK03202
      Location:2 → 319
      PRK03202; ATP-dependent 6-phosphofructokinase
    Nucleotide Protein
    Heading Accession and Version

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