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    fimH type 1 fimbriae D-mannose specific adhesin [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948847, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fimH
    Official Full Name
    type 1 fimbriae D-mannose specific adhesin
    Primary source
    ECOCYC:EG10315
    Locus tag
    b4320
    See related
    ASAP:ABE-0014157
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4311; pilE
    Summary
    Mutants of FimH have been isolated that auto-aggregate. [More information is available at EcoGene: EG10315]. Type 1, or mannose-sensitive, fimbriae in Escherichia coli mediate binding to receptor structures allowing the bacteria to colonize various host tissues. [More information is available at EcoCyc: EG10315].
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    Genomic context

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    Sequence:
    NC_000913.3 (4548808..4549710)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene type 1 fimbriae minor subunit FimF Neighboring gene type 1 fimbriae minor subunit FimG Neighboring gene fructuronate transporter Neighboring gene D-mannonate dehydratase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative analysis of nonequilibrium, denaturant-dependent protein folding transitions. Erilov D, et al. J Am Chem Soc, 2007 Jul 25. PMID 17602628
    2. Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding. Chen SL, et al. Proc Natl Acad Sci U S A, 2009 Dec 29. PMID 20018753, Free PMC Article
    3. Identification of two ancillary subunits of Escherichia coli type 1 fimbriae by using antibodies against synthetic oligopeptides of fim gene products. Abraham SN, et al. J Bacteriol, 1987 Dec. PMID 2890622, Free PMC Article
    4. FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling. Ashkar AA, et al. PLoS Pathog, 2008 Dec. PMID 19057665, Free PMC Article
    5. Adaptive mutations in the signal peptide of the type 1 fimbrial adhesin of uropathogenic Escherichia coli. Ronald LS, et al. Proc Natl Acad Sci U S A, 2008 Aug 5. PMID 18664574, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FimH-mannose noncovalent bonds survive minutes to hours under force.
      Title: FimH-mannose noncovalent bonds survive minutes to hours under force.
    2. Escherichia coli adhesion protein FimH exacerbates colitis via CD11b[+]CD103[-] dendritic cell activation.
      Title: Escherichia coli adhesion protein FimH exacerbates colitis via CD11b(+)CD103(-) dendritic cell activation.
    3. Escherichia coli adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4.
      Title: Escherichia coli adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4.
    4. Recombinant FimH Adhesin Demonstrates How the Allosteric Catch Bond Mechanism Can Support Fast and Strong Bacterial Attachment in the Absence of Shear.
      Title: Recombinant FimH Adhesin Demonstrates How the Allosteric Catch Bond Mechanism Can Support Fast and Strong Bacterial Attachment in the Absence of Shear.
    5. Escherichia coli FimH adhesins act synergistically with PapGII adhesins for enhancing establishment and maintenance of kidney infection.
      Title: Escherichia coli FimH adhesins act synergistically with PapGII adhesins for enhancing establishment and maintenance of kidney infection.
    6. Structural and functional characterization of the FimH adhesin of uropathogenic Escherichia coli and its novel applications.
      Title: Structural and functional characterization of the FimH adhesin of uropathogenic Escherichia coli and its novel applications.
    7. Conformational stability of the bacterial adhesin, FimH, with an inactivating mutation.
      Title: Conformational stability of the bacterial adhesin, FimH, with an inactivating mutation.
    8. RMSD analysis of structures of the bacterial protein FimH identifies five conformations of its lectin domain.
      Title: RMSD analysis of structures of the bacterial protein FimH identifies five conformations of its lectin domain.
    9. Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain.
      Title: Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system.
    10. Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
      Title: Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables D-mannose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion involved in single-species biofilm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in host cell membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in pilus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pilus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pilus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in pilus tip IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type 1 fimbriae D-mannose specific adhesin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4548808..4549710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418740.1 type 1 fimbriae D-mannose specific adhesin [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418740.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9F5S0, Q9F5S1, Q9S496, Q9S497
      Conserved Domains (2) summary
      pfam09160
      Location:25 → 168
      FimH_man-bind; FimH, mannose binding
      cl01416
      Location:182 → 300
      Fimbrial; Fimbrial protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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