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    serB phosphoserine phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948913, updated on 3-Dec-2024

    Summary

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    Official Symbol
    serB
    Official Full Name
    phosphoserine phosphatase
    Primary source
    ECOCYC:EG10945
    Locus tag
    b4388
    See related
    ASAP:ABE-0014393
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4380
    Summary
    HAD superfamily. [More information is available at EcoGene: EG10945]. Phosphoserine phosphatase catalyzes the last step in serine biosynthesis. [More information is available at EcoCyc: EG10945].
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    Genomic context

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    Sequence:
    NC_000913.3 (4624895..4625863)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipoate--protein ligase A Neighboring gene putative inner membrane protein Smp Neighboring gene DNA recombination protein Neighboring gene DNA-binding transcriptional repressor/NMN adenylyltransferase NadR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. THE PATHWAY AND CONTROL OF SERINE BIOSYNTHESIS IN ESCHERICHIA COLI. PIZER LI. J Biol Chem, 1963 Dec. PMID 14086727
    2. DNA sequence and characterization of the Escherichia coli serB gene. Neuwald AF, et al. Nucleic Acids Res, 1985 Oct 11. PMID 2997734, Free PMC Article
    3. Construction and analysis of plasmids containing the Escherichia coli serB gene. Garnant MK, et al. Mol Gen Genet, 1984. PMID 6318053
    4. Mutational analysis of the Escherichia coli serB promoter region reveals transcriptional linkage to a downstream gene. Neuwald AF, et al. Gene, 1992 Oct 12. PMID 1327967
    5. BIOSYNTHESIS OF SERINE IN ESCHERICHIA COLI AND SALMONELLA TYPHIMURIUM. UMBARGER HE, et al. J Bacteriol, 1963 Jun. PMID 14047241, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-phosphoserine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-phosphoserine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-phosphoserine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-serine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-serine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-serine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within amino acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoserine phosphatase
    NP_418805.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4624895..4625863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418805.1 phosphoserine phosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418805.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DYT7, A0A8S7EK95, A0AAN5ZJ10
      Conserved Domains (1) summary
      PRK11133
      Location:1 → 322
      serB; phosphoserine phosphatase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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