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    tsf protein chain elongation factor EF-Ts [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944866, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tsf
    Official Full Name
    protein chain elongation factor EF-Ts
    Primary source
    ECOCYC:EG11033
    Locus tag
    b0170
    See related
    ASAP:ABE-0000579
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0169
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11033]. EF-Ts is an elongation factor associated with the ribosome; it functions as the guanine nucleotide exchange factor for the EF-Tu GTPase. [More information is available at EcoCyc: EG11033].
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    Genomic context

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    Sequence:
    NC_000913.3 (190857..191708)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 30S ribosomal subunit protein S2 Neighboring gene UMP kinase Neighboring gene ribosome-recycling factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetic studies on the interactions of Escherichia coli K12 elongation factor Tu with GDP and elongation factor Ts. Chau V, et al. J Biol Chem, 1981 Jun 10. PMID 7016856
    2. Qbeta-phage resistance by deletion of the coiled-coil motif in elongation factor Ts. Karring H, et al. J Biol Chem, 2004 Jan 16. PMID 14583631
    3. Elongation factors in protein biosynthesis. Andersen GR, et al. Trends Biochem Sci, 2003 Aug. PMID 12932732
    4. Kinetic mechanism of elongation factor Ts-catalyzed nucleotide exchange in elongation factor Tu. Gromadski KB, et al. Biochemistry, 2002 Jan 8. PMID 11772013
    5. Elongation factor Ts can act as a steric chaperone by increasing the solubility of nucleotide binding-impaired elongation factor-Tu. Krab IM, et al. Biochemistry, 2001 Jul 24. PMID 11456491

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. S2 functions as a negative regulator of both its own and tsf expression in vivo.
      Title: A new regulatory circuit in ribosomal protein operons: S2-mediated control of the rpsB-tsf expression in vivo.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    3. Tsf is identified as an aggregation-resistant protein through proteome-wide analysis in response to a protein denaturant.
      Title: Enhanced solubility of heterologous proteins by fusion expression using stress-induced Escherichia coli protein, Tsf.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    protein chain elongation factor EF-Ts

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      190857..191708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414712.1 protein chain elongation factor EF-Ts [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414712.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0M3KKV2
      Conserved Domains (1) summary
      PRK09377
      Location:1 → 281
      tsf; elongation factor Ts; Provisional
    Nucleotide Protein
    Heading Accession and Version

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