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    pgaA partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945596, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pgaA
    Official Full Name
    partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin
    Primary source
    ECOCYC:G6531
    Locus tag
    b1024
    See related
    ASAP:ABE-0003469
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1014; hmsH; ycdS
    Summary
    PgaA is homolgous to Y. pestis hemin storage protein HmsH, but is unable to complement hmsH mutations. [More information is available at EcoGene: EG13865]. The pgaABCD locus is required for the synthesis of a cell-bound hexosamine-rich polysaccharide, which was identified as a linear polymer of beta-1,6-N-acetylglucosamine residues (PGA), an adhesin essential in biofilm formation . [More information is available at EcoCyc: G6531].
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    Genomic context

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    Sequence:
    NC_000913.3 (1089866..1092289, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene poly-N-acetyl-D-glucosamine synthase subunit PgaD Neighboring gene poly-N-acetyl-D-glucosamine synthase subunit PgaC Neighboring gene poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase and beta-1,6 glycoside hydrolase Neighboring gene putative diguanylate cyclase DgcT Neighboring gene IS3 element protein InsF Neighboring gene IS3 element protein InsE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depolymerization of beta-1,6-N-acetyl-D-glucosamine disrupts the integrity of diverse bacterial biofilms. Itoh Y, et al. J Bacteriol, 2005 Jan. PMID 15601723, Free PMC Article
    2. HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis. Jones HA, et al. Microbiology (Reading), 1999 Aug. PMID 10463178
    3. Effect of growth conditions on poly-N-acetylglucosamine expression and biofilm formation in Escherichia coli. Cerca N, et al. FEMS Microbiol Lett, 2008 Jun. PMID 18445167
    4. Spatial periodicity of Escherichia coli K-12 biofilm microstructure initiates during a reversible, polar attachment phase of development and requires the polysaccharide adhesin PGA. Agladze K, et al. J Bacteriol, 2005 Dec. PMID 16321928, Free PMC Article
    5. Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress. Boehm A, et al. Mol Microbiol, 2009 Jun. PMID 19460094

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polysaccharide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polysaccharide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within polysaccharide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within polysaccharide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1089866..1092289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415543.1 partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415543.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6PYQ1
      Conserved Domains (2) summary
      PRK10049
      Location:53 → 807
      pgaA; outer membrane protein PgaA; Provisional
      sd00006
      Location:98 → 126
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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