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    pntA pyridine nucleotide transhydrogenase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946628, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pntA
    Official Full Name
    pyridine nucleotide transhydrogenase subunit alpha
    Primary source
    ECOCYC:EG10744
    Locus tag
    b1603
    See related
    ASAP:ABE-0005354
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1598
    Summary
    [More information is available at EcoGene: EG10744]. Pyridine nucleotide transhydrogenase catalyzes the reversible transfer of a hydride ion equivalent between NAD and NADP. [More information is available at EcoCyc: EG10744].
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    Genomic context

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    Sequence:
    NC_000913.3 (1676371..1677903, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene autoinducer 2 exporter Neighboring gene pyridine nucleotide transhydrogenase subunit beta Neighboring gene DUF1471 domain-containing protein YdgH Neighboring gene putative arginine:ornithine antiporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Energization of energy-dependent transhydrogenase of Escherichia coli at a second site of energy conservation. Bragg PD, et al. Arch Biochem Biophys, 1974 Aug. PMID 4153348
    2. Involvement of histidine-91 of the beta subunit in proton translocation by the pyridine nucleotide transhydrogenase of Escherichia coli. Glavas NA, et al. Biochemistry, 1995 Jun 13. PMID 7779816
    3. Why are two different types of pyridine nucleotide transhydrogenase found in living organisms? Voordouw G, et al. Eur J Biochem, 1983 Apr 5. PMID 6840064
    4. Structural aspects of the membrane-bound Escherichia colipyridine nucleotide transhydrogenase (EC 1.6.1.1). Liang A, et al. FEBS Lett, 1980 Jan 14. PMID 6986284
    5. Effects of an insertion mutation in a locus affecting pyridine nucleotide transhydrogenase (pnt::Tn5) on the growth of Escherichia coli. Hanson RL, et al. J Bacteriol, 1980 Jan. PMID 6986364, Free PMC Article

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct transcription factors regulated the PntA, PntB and UdhA promoters.
      Title: Distinct transcriptional regulation of the two Escherichia coli transhydrogenases PntAB and UdhA.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Nucleotide sequence of the pntA and pntB genes encoding the pyridine nucleotide transhydrogenase of Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton-translocating NAD(P)+ transhydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton-translocating NAD(P)+ transhydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADPH regeneration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NADPH regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyridine nucleotide transhydrogenase subunit alpha
    NP_416120.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1676371..1677903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416120.1 pyridine nucleotide transhydrogenase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416120.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8QRY8, A0A8S7FGR8
      Conserved Domains (1) summary
      PRK09424
      Location:1 → 509
      pntA; Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha
    Nucleotide Protein
    Heading Accession and Version

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