nrdE ribonucleoside-diphosphate reductase 2 subunit alpha [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: nrdE
Official Full Name: ribonucleoside-diphosphate reductase 2 subunit alpha
Primary source: ECOCYC:EG20257
Locus tag: b2675
See related: ASAP:ABE-0008806
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2669
Summary: nrdE is a nonessential gene. [More information is available at EcoGene: EG20257]. Expression of the nrdHIEF operon is increased by hydroxyurea and oxidative stress . [More information is available at EcoCyc: EG20257].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Thus NrdEF supports DNA replication when iron is unavailable to activate the housekeeping NrdAB enzyme.
Title: The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation.
Functional long-range proton-coupled electron transfer in ribonucleoside diphosphate reductase occurs via an optimized pathway of amino acids spanning >35 A across the alpha:beta interface.
Title: Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEA Inferred from Electronic Annotation more info
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nucleobase-containing small molecule interconversion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribonucleoside diphosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ribonucleoside-diphosphate reductase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoside-diphosphate reductase complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of ribonucleoside-diphosphate reductase complex	ISS Inferred from Sequence or Structural Similarity more info

NP_417161.1

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The following sections contain reference sequences that belong to a specific genome build. Explain