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    emrA multidrug efflux pump membrane fusion protein EmrA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947166, updated on 3-Dec-2024

    Summary

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    Official Symbol
    emrA
    Official Full Name
    multidrug efflux pump membrane fusion protein EmrA
    Primary source
    ECOCYC:EG11354
    Locus tag
    b2685
    See related
    ASAP:ABE-0008838
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2679
    Summary
    EmrA is the membrane fusion protein for the EmrB multidrug efflux pump. [More information is available at EcoCyc: EG11354].
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    Genomic context

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    Sequence:
    NC_000913.3 (2811427..2812599)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-valine exporter, YgaZ component Neighboring gene L-valine exporter, YgaH component Neighboring gene DNA-binding transcriptional regulator MprA Neighboring gene multidrug efflux pump membrane subunit EmrB Neighboring gene S-ribosylhomocysteine lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural characterization of the EmrAB-TolC efflux complex from E. coli. Yousefian N, et al. Biochim Biophys Acta Biomembr, 2021 Jan 1. PMID 33065135
    2. Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance. Lomovskaya O, et al. Antimicrob Agents Chemother, 1996 Apr. PMID 8849229, Free PMC Article
    3. Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB. Furukawa H, et al. J Bacteriol, 1993 Jun. PMID 8509326, Free PMC Article
    4. Purification and ligand binding of EmrR, a regulator of a multidrug transporter. Brooun A, et al. J Bacteriol, 1999 Aug. PMID 10438794, Free PMC Article
    5. The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region. Xiong A, et al. Antimicrob Agents Chemother, 2000 Oct. PMID 10991887, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural characterization of the EmrAB-TolC efflux complex from E. coli.
      Title: Structural characterization of the EmrAB-TolC efflux complex from E. coli.
    2. Data suggest that recruitment of TolC by various MFPs AcrA, MacA, and EmrA is determined not only by kinetics of MFP-TolC interactions but also by oligomerization kinetics of MFPs and pH.
      Title: Kinetic control of TolC recruitment by multidrug efflux complexes.
    3. This study was aimed to obtain a reliable estimate of the stoichiometry of the EmrAB complex.
      Title: The multidrug resistance efflux complex, EmrAB from Escherichia coli forms a dimer in vitro.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bile acid and bile salt transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to steroid hormone EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of efflux pump complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in periplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multidrug efflux pump membrane fusion protein EmrA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2811427..2812599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417170.1 multidrug efflux pump membrane fusion protein EmrA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417170.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7YE87
      Conserved Domains (1) summary
      PRK15136
      Location:1 → 390
      PRK15136; multidrug efflux MFS transporter periplasmic adaptor subunit EmrA
    Nucleotide Protein
    Heading Accession and Version

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