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    aldB aldehyde dehydrogenase B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948104, updated on 17-Dec-2024

    Summary

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    Official Symbol
    aldB
    Official Full Name
    aldehyde dehydrogenase B
    Primary source
    ECOCYC:EG12292
    Locus tag
    b3588
    See related
    ASAP:ABE-0011718
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3577; yiaX
    Summary
    AldB has NADP-dependent acetaldehyde dehydrogenase activity , which may be identical to the activity detected by Heim and Strehler in crude cell extracts . [More information is available at EcoCyc: EG12292].
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    Genomic context

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    Sequence:
    NC_000913.3 (3754973..3756511, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative DNA-binding transcriptional regulator YiaU Neighboring gene putative membrane fusion protein YiaV Neighboring gene DUF3302 domain-containing protein YiaW Neighboring gene L-threonine dehydrogenase Neighboring gene selenocysteyl-tRNA-specific translation elongation factor Neighboring gene selenocysteine synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AldB controls persister formation in Escherichia coli depending on environmental stress. Kawai Y, et al. Microbiol Immunol, 2018 May. PMID 29577369
    2. aldB, an RpoS-dependent gene in Escherichia coli encoding an aldehyde dehydrogenase that is repressed by Fis and activated by Crp. Xu J, et al. J Bacteriol, 1995 Jun. PMID 7768815, Free PMC Article
    3. Transposon mutagenesis identifies genes which control antimicrobial drug tolerance in stationary-phase Escherichia coli. Hu Y, et al. FEMS Microbiol Lett, 2005 Feb 1. PMID 15668009
    4. Identification of genes negatively regulated by Fis: Fis and RpoS comodulate growth-phase-dependent gene expression in Escherichia coli. Xu J, et al. J Bacteriol, 1995 Feb. PMID 7860604, Free PMC Article
    5. Cloning an Escherichia coli gene encoding a protein remarkably similar to mammalian aldehyde dehydrogenases. Heim R, et al. Gene, 1991 Mar 1. PMID 1840553

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AldB controls persister formation in Escherichia coli depending on environmental stress.
      Title: AldB controls persister formation in Escherichia coli depending on environmental stress.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Isolation and characterization of an aldehyde dehydrogenase encoded by the aldB gene of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldehyde dehydrogenase B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3754973..3756511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418045.4 aldehyde dehydrogenase B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418045.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FUR7
      Conserved Domains (1) summary
      cd07559
      Location:25 → 504
      ALDH_ACDHII_AcoD-like; Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like
    Nucleotide Protein
    Heading Accession and Version

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