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    guaC GMP reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948986, updated on 3-Dec-2024

    Summary

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    Official Symbol
    guaC
    Official Full Name
    GMP reductase
    Primary source
    ECOCYC:EG10422
    Locus tag
    b0104
    See related
    ASAP:ABE-0000362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0104
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    Genomic context

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    Sequence:
    NC_000913.3 (113444..114487)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division factor ZapD Neighboring gene dephospho-CoA kinase Neighboring gene protein YacM Neighboring gene inner membrane protein HofC Neighboring gene T2SSE family protein Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recombinant Escherichia coli GMP reductase: kinetic, catalytic and chemical mechanisms, and thermodynamics of enzyme-ligand binary complex formation. Martinelli LK, et al. Mol Biosyst, 2011 Apr. PMID 21298178
    2. Regulation of guaC expression in Escherichia coli. Kessler AI, et al. J Bacteriol, 1985 Dec. PMID 2999079, Free PMC Article
    3. Cloning of the Escherichia coli K-12 guaC gene following its transposition into the RP4::Mu cointegrate. Moffat KG, et al. Gene, 1985. PMID 3005121
    4. Requirement of cyclic AMP for induction of GMP reductase in Escherichia coli. Benson CE, et al. Biochem Biophys Res Commun, 1971 Jun 4. PMID 4327955
    5. Genetic and biochemical studies of the guanosine 5'-monophosphate pathway in Escherichia coli. Nijkamp HJ, et al. Biochim Biophys Acta, 1967 Aug 22. PMID 4861262

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There are relative dynamics of substrate and cofactor exchange during the GMP reductase catalytic cycle.
      Title: Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probed by High Resolution Field Cycling 31P NMR Relaxometry.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GMP reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IMP salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine ribonucleotide interconversion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GMP reductase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GMP reductase
    NP_414646.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      113444..114487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414646.1 GMP reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414646.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MQV2
      Conserved Domains (1) summary
      PRK05096
      Location:1 → 346
      PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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