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    gmhB D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944879, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gmhB
    Official Full Name
    D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase
    Primary source
    ECOCYC:EG11736
    Locus tag
    b0200
    See related
    ASAP:ABE-0000675
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0200; yaeD
    Summary
    gmhB encodes the D,D-heptose 1,7-bisphosphate phosphatase of the ADP-heptose biosynthesis pathway. [More information is available at EcoCyc: EG11736].
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    Genomic context

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    Sequence:
    NC_000913.3 (222833..223408)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-methionine/D-methionine ABC transporter membrane anchored binding protein Neighboring gene L-methionine/D-methionine ABC transporter membrane subunit Neighboring gene L-methionine/D-methionine ABC transporter ATP binding subunit Neighboring gene 16S ribosomal RNA Neighboring gene tRNA-Ile

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli. Taylor PL, et al. Biochemistry, 2010 Feb 9. PMID 20050699
    2. Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) . Nguyen HH, et al. Biochemistry, 2010 Feb 16. PMID 20050614, Free PMC Article
    3. Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB). Wang L, et al. Biochemistry, 2010 Feb 16. PMID 20050615, Free PMC Article
    4. Genome-wide screens: novel mechanisms in colicin import and cytotoxicity. Sharma O, et al. Mol Microbiol, 2009 Aug. PMID 19650773, Free PMC Article
    5. Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli. Brown G, et al. J Biol Chem, 2009 Feb 6. PMID 19073594, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E. coli GmhB is characterized as a D-dlycero-D-manno-heptose-1,7-bisphosphate (HAD) phosphatase with a narrow substrate range and a high catalytic efficiency toward its physiological substrate.
      Title: Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).
    2. GmhB and the histidinol-phosphate phosphatase domain use the same design of three substrate recognition loops inserted into the cap domain yet have achieved unique substrate specificity and thus novel biochemical function.
      Title: Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) .
    3. GmhB functions through a phosphoaspartate intermediate catalyzing the third essential step of lipopolysaccharide/heptose biosynthesis.
      Title: Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ADP-L-glycero-beta-D-manno-heptose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase
    NP_414742.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      222833..223408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414742.1 D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414742.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A447XA09
      Conserved Domains (1) summary
      TIGR00213
      Location:5 → 181
      GmhB_yaeD; D,D-heptose 1,7-bisphosphate phosphatase
    Nucleotide Protein
    Heading Accession and Version

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