phoR sensor histidine kinase PhoR [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: phoR
Official Full Name: sensor histidine kinase PhoR
Primary source: ECOCYC:EG10733
Locus tag: b0400
See related: ASAP:ABE-0001391
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0394; nmpB; phoR1; R1pho
Summary: Phosphate regulon sensor kinase-phosphotransferase PhoR is probably a dimer or higher oligomer. [More information is available at EcoCyc: EG10733].
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NC_000913.3 Genomic Context describing neighboring genes

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PhoU interacts with PhoR, PstB, and metals to form a phosphate-signaling complex at the membrane.
Title: The PhoU protein from Escherichia coli interacts with PhoR, PstB, and metals to form a phosphate-signaling complex at the membrane.
Findings indicate that the mode of autophosphorylation is highly conserved and that orthologs of EnvZ and PhoR with diverse loops autophosphorylated in trans and in cis, respectively.
Title: Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.
Protein interaction analyses reveal binding of EIIA(Ntr) to histidine kinase PhoR.
Title: The phosphotransferase protein EIIA(Ntr) modulates the phosphate starvation response through interaction with histidine kinase PhoR in Escherichia coli.
CreC showed an interaction with PhoB, before an interaction between PhoB and PhoR, suggesting that this acts as a constant sensor for the early response to phosphate starvation.
Title: Transcript and protein level analyses of the interactions among PhoB, PhoR, PhoU and CreC in response to phosphate starvation in Escherichia coli.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphorelay sensor kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorelay sensor kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphorelay sensor kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to phosphate starvation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to phosphate starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in phosphate ion transport	IEA Inferred from Electronic Annotation more info
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_414934.1

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